2.50
Hdl Handle:
http://hdl.handle.net/10541/109491
Title:
Abdominal irradiation in childhood; the potential for pregnancy.
Authors:
Critchley, H O; Wallace, W Hamish B; Shalet, Stephen M; Mamtora, H; Higginson, J; Anderson, D C
Abstract:
OBJECTIVE: To investigate the impact of premature ovarian failure due to whole abdominal radiotherapy (DXT) in childhood on uterine physical characteristics and blood flow and measuring the uterine response to exogenous sex steroid replacement. DESIGN: A comparative observational study SUBJECTS: 10 women with premature ovarian failure due to treatment with whole abdominal irradiation in childhood. A comparison group of 22 women with premature ovarian failure who had not received whole abdominal DXT. MAIN OUTCOME MEASURES: Uterine length and uterine blood flow measurement plus serial assessment of endometrial thickness during a cycle of exogenous sex steroid replacement. RESULTS: Uterine length was significantly less (P less than 0.01) in women who had been exposed to whole abdominal DXT in childhood (mean 4.1 cm, 2SE 0.8) compared with a mean of 7.3 cm (2SE 0.6) in the comparison group. The three women in the DXT group who were studied serially had no increase in endometrial thickness in response to physiological sex steroid replacement therapy and most of the 10 irradiated women had no detectable uterine blood flow with Doppler ultrasound. CONCLUSIONS: Uterine musculature and blood flow are irreversibly affected by high dose irradiation in childhood. Non-invasive assessment of this nature may predict potential for pregnancy following ovum donation and embryo transfer.
Affiliation:
Department of Obstetrics and Gynaecology, St. Mary's Hospital, Manchester, UK.
Citation:
Abdominal irradiation in childhood; the potential for pregnancy. 1992, 99 (5):392-4 Br J Obstet Gynaecol
Journal:
British Journal of Obstetrics and Gynaecology
Issue Date:
May-1992
URI:
http://hdl.handle.net/10541/109491
PubMed ID:
1622911
Type:
Article
Language:
en
ISSN:
0306-5456
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorCritchley, H Oen
dc.contributor.authorWallace, W Hamish Ben
dc.contributor.authorShalet, Stephen Men
dc.contributor.authorMamtora, Hen
dc.contributor.authorHigginson, Jen
dc.contributor.authorAnderson, D Cen
dc.date.accessioned2010-08-11T16:20:24Z-
dc.date.available2010-08-11T16:20:24Z-
dc.date.issued1992-05-
dc.identifier.citationAbdominal irradiation in childhood; the potential for pregnancy. 1992, 99 (5):392-4 Br J Obstet Gynaecolen
dc.identifier.issn0306-5456-
dc.identifier.pmid1622911-
dc.identifier.urihttp://hdl.handle.net/10541/109491-
dc.description.abstractOBJECTIVE: To investigate the impact of premature ovarian failure due to whole abdominal radiotherapy (DXT) in childhood on uterine physical characteristics and blood flow and measuring the uterine response to exogenous sex steroid replacement. DESIGN: A comparative observational study SUBJECTS: 10 women with premature ovarian failure due to treatment with whole abdominal irradiation in childhood. A comparison group of 22 women with premature ovarian failure who had not received whole abdominal DXT. MAIN OUTCOME MEASURES: Uterine length and uterine blood flow measurement plus serial assessment of endometrial thickness during a cycle of exogenous sex steroid replacement. RESULTS: Uterine length was significantly less (P less than 0.01) in women who had been exposed to whole abdominal DXT in childhood (mean 4.1 cm, 2SE 0.8) compared with a mean of 7.3 cm (2SE 0.6) in the comparison group. The three women in the DXT group who were studied serially had no increase in endometrial thickness in response to physiological sex steroid replacement therapy and most of the 10 irradiated women had no detectable uterine blood flow with Doppler ultrasound. CONCLUSIONS: Uterine musculature and blood flow are irreversibly affected by high dose irradiation in childhood. Non-invasive assessment of this nature may predict potential for pregnancy following ovum donation and embryo transfer.en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshBlood Flow Velocity-
dc.subject.meshEndometrium-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshOvarian Failure, Premature-
dc.subject.meshRadiotherapy-
dc.subject.meshUterus-
dc.titleAbdominal irradiation in childhood; the potential for pregnancy.en
dc.typeArticleen
dc.contributor.departmentDepartment of Obstetrics and Gynaecology, St. Mary's Hospital, Manchester, UK.en
dc.identifier.journalBritish Journal of Obstetrics and Gynaecologyen
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