Immunohistochemical localisation of transforming growth factor-beta in first and third trimester human placenta.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109489
Title:
Immunohistochemical localisation of transforming growth factor-beta in first and third trimester human placenta.
Authors:
Vuckovic, M; Genbacev, O; Kumar, Shant
Abstract:
Recently it has been demonstrated that human placental tissue is a source of transforming growth factor-beta (TGF-beta) and that it expresses high TGF-beta mRNA activity. For a better understanding of its in vivo function, it was necessary to determine the site of TGF-beta synthesis in placenta. We have demonstrated that TGF-beta immunoreactivity is present in the cytoplasm of syncytiotrophoblast cells in both early and term placenta. The most intense staining was, however, observed in the first trimester trophoblast syncytial sprouts known to be an early stage in the development of placental villi. These results suggest the involvement of TGF-beta in the paracrine regulation of trophoblast-endometrial interaction.
Affiliation:
Institute of Endocrinology, Immunology and Nutrition, INEPT, Semun, Yugoslavia.
Citation:
Immunohistochemical localisation of transforming growth factor-beta in first and third trimester human placenta. 1992, 60 (3):149-51 Pathobiology
Journal:
Pathobiology
Issue Date:
1992
URI:
http://hdl.handle.net/10541/109489
DOI:
10.1159/000163714
PubMed ID:
1627260
Type:
Article
Language:
en
ISSN:
1015-2008
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorVuckovic, Men
dc.contributor.authorGenbacev, Oen
dc.contributor.authorKumar, Shanten
dc.date.accessioned2010-08-11T15:40:56Z-
dc.date.available2010-08-11T15:40:56Z-
dc.date.issued1992-
dc.identifier.citationImmunohistochemical localisation of transforming growth factor-beta in first and third trimester human placenta. 1992, 60 (3):149-51 Pathobiologyen
dc.identifier.issn1015-2008-
dc.identifier.pmid1627260-
dc.identifier.doi10.1159/000163714-
dc.identifier.urihttp://hdl.handle.net/10541/109489-
dc.description.abstractRecently it has been demonstrated that human placental tissue is a source of transforming growth factor-beta (TGF-beta) and that it expresses high TGF-beta mRNA activity. For a better understanding of its in vivo function, it was necessary to determine the site of TGF-beta synthesis in placenta. We have demonstrated that TGF-beta immunoreactivity is present in the cytoplasm of syncytiotrophoblast cells in both early and term placenta. The most intense staining was, however, observed in the first trimester trophoblast syncytial sprouts known to be an early stage in the development of placental villi. These results suggest the involvement of TGF-beta in the paracrine regulation of trophoblast-endometrial interaction.en
dc.language.isoenen
dc.subject.meshChorionic Villi-
dc.subject.meshCytoplasm-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunoenzyme Techniques-
dc.subject.meshPlacenta-
dc.subject.meshPregnancy-
dc.subject.meshPregnancy Proteins-
dc.subject.meshPregnancy Trimester, First-
dc.subject.meshPregnancy Trimester, Third-
dc.subject.meshTransforming Growth Factor beta-
dc.subject.meshTrophoblasts-
dc.titleImmunohistochemical localisation of transforming growth factor-beta in first and third trimester human placenta.en
dc.typeArticleen
dc.contributor.departmentInstitute of Endocrinology, Immunology and Nutrition, INEPT, Semun, Yugoslavia.en
dc.identifier.journalPathobiologyen
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