Pseudoangiosarcomatous carcinoma: a clinicopathological study of seven cases.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109486
Title:
Pseudoangiosarcomatous carcinoma: a clinicopathological study of seven cases.
Authors:
Banerjee, Saumitra S; Eyden, Brian P; Wells, S; McWilliam, L J; Harris, Martin
Abstract:
Seven cases of carcinoma mimicking angiosarcoma occurring in skin (3 cases), breast (3) and lung (1) are described. The cutaneous, pulmonary and one of the breast carcinomas were poorly differentiated and squamous in type; the other two breast tumours were poorly differentiated ductal carcinomas with focal squamous differentiation. Histologically, the pseudoangiosarcomatous pattern was due to complex anastomosing channels and spaces lined by neoplastic cells. The spaces contained hyaluronic acid. The neoplastic cells exhibited cytokeratin positivity but yielded negative results with the endothelial cell markers, factor VIII-related antigen and CD 34 (QB-END/10). Two breast tumours showed binding of UEA-1. Ultrastructurally, unequivocal epithelial differentiation was demonstrated in six of the cases. Pathogenetically, these tumours appeared to be variants of acantholytic squamous cell carcinoma. Recognition of this unusual form of carcinoma is important, as an incorrect diagnosis of angiosarcoma may lead to inappropriate treatment and prognostication.
Affiliation:
Department of Histopathology, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Pseudoangiosarcomatous carcinoma: a clinicopathological study of seven cases. 1992, 21 (1):13-23 Histopathology
Journal:
Histopathology
Issue Date:
Jul-1992
URI:
http://hdl.handle.net/10541/109486
DOI:
10.1111/j.1365-2559.1992.tb00338.x
PubMed ID:
1634198
Type:
Article
Language:
en
ISSN:
0309-0167
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBanerjee, Saumitra Sen
dc.contributor.authorEyden, Brian Pen
dc.contributor.authorWells, Sen
dc.contributor.authorMcWilliam, L Jen
dc.contributor.authorHarris, Martinen
dc.date.accessioned2010-08-11T15:26:00Z-
dc.date.available2010-08-11T15:26:00Z-
dc.date.issued1992-07-
dc.identifier.citationPseudoangiosarcomatous carcinoma: a clinicopathological study of seven cases. 1992, 21 (1):13-23 Histopathologyen
dc.identifier.issn0309-0167-
dc.identifier.pmid1634198-
dc.identifier.doi10.1111/j.1365-2559.1992.tb00338.x-
dc.identifier.urihttp://hdl.handle.net/10541/109486-
dc.description.abstractSeven cases of carcinoma mimicking angiosarcoma occurring in skin (3 cases), breast (3) and lung (1) are described. The cutaneous, pulmonary and one of the breast carcinomas were poorly differentiated and squamous in type; the other two breast tumours were poorly differentiated ductal carcinomas with focal squamous differentiation. Histologically, the pseudoangiosarcomatous pattern was due to complex anastomosing channels and spaces lined by neoplastic cells. The spaces contained hyaluronic acid. The neoplastic cells exhibited cytokeratin positivity but yielded negative results with the endothelial cell markers, factor VIII-related antigen and CD 34 (QB-END/10). Two breast tumours showed binding of UEA-1. Ultrastructurally, unequivocal epithelial differentiation was demonstrated in six of the cases. Pathogenetically, these tumours appeared to be variants of acantholytic squamous cell carcinoma. Recognition of this unusual form of carcinoma is important, as an incorrect diagnosis of angiosarcoma may lead to inappropriate treatment and prognostication.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectLung Canceren
dc.subjectSkin Canceren
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshBreast Neoplasms-
dc.subject.meshDiagnosis, Differential-
dc.subject.meshFemale-
dc.subject.meshHemangiosarcoma-
dc.subject.meshHistocytochemistry-
dc.subject.meshHumans-
dc.subject.meshImmunoenzyme Techniques-
dc.subject.meshLung Neoplasms-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshSkin Neoplasms-
dc.titlePseudoangiosarcomatous carcinoma: a clinicopathological study of seven cases.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalHistopathologyen

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