Does hyaluronan have a role in endothelial cell proliferation of the synovium?

2.50
Hdl Handle:
http://hdl.handle.net/10541/109484
Title:
Does hyaluronan have a role in endothelial cell proliferation of the synovium?
Authors:
Sattar, A; Kumar, Shant; West, David C
Abstract:
Hyaluranate (HA) is a major constituent of synovial fluid, but its concentration and molecular size differ in normal and inflamed joints. HA can induce or inhibit angiogenesis depending on both its size and its concentration. Endothelial-cell endocytose-labeled macromolecular HA and HA oligosaccharides and binding studies have identified an HA-specific receptor on the endothelial cell surface (KD, 10(-10) mol/L; approximately 2,000/cell). The molecular weight of HA-binding proteins was found to be 90 to 125, 78, and 46 kd.
Affiliation:
Clinical Research Laboratories, Christie Hospital and Holt Radium Institute, Manchester, England.
Citation:
Does hyaluronan have a role in endothelial cell proliferation of the synovium? 1992, 22 (1):37-43 Semin. Arthritis Rheum
Journal:
Seminars in Arthritis and Rheumatism
Issue Date:
Aug-1992
URI:
http://hdl.handle.net/10541/109484
DOI:
10.1016/0049-0172(92)90047-H
PubMed ID:
1384133
Type:
Article
Language:
en
ISSN:
0049-0172
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorSattar, Aen
dc.contributor.authorKumar, Shanten
dc.contributor.authorWest, David Cen
dc.date.accessioned2010-08-11T14:37:00Z-
dc.date.available2010-08-11T14:37:00Z-
dc.date.issued1992-08-
dc.identifier.citationDoes hyaluronan have a role in endothelial cell proliferation of the synovium? 1992, 22 (1):37-43 Semin. Arthritis Rheumen
dc.identifier.issn0049-0172-
dc.identifier.pmid1384133-
dc.identifier.doi10.1016/0049-0172(92)90047-H-
dc.identifier.urihttp://hdl.handle.net/10541/109484-
dc.description.abstractHyaluranate (HA) is a major constituent of synovial fluid, but its concentration and molecular size differ in normal and inflamed joints. HA can induce or inhibit angiogenesis depending on both its size and its concentration. Endothelial-cell endocytose-labeled macromolecular HA and HA oligosaccharides and binding studies have identified an HA-specific receptor on the endothelial cell surface (KD, 10(-10) mol/L; approximately 2,000/cell). The molecular weight of HA-binding proteins was found to be 90 to 125, 78, and 46 kd.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshAntigens, CD44-
dc.subject.meshAorta-
dc.subject.meshCell Division-
dc.subject.meshCell Movement-
dc.subject.meshCells, Cultured-
dc.subject.meshCerebrovascular Circulation-
dc.subject.meshEndothelium, Vascular-
dc.subject.meshHyaluronic Acid-
dc.subject.meshReceptors, Cell Surface-
dc.subject.meshSynovial Membrane-
dc.titleDoes hyaluronan have a role in endothelial cell proliferation of the synovium?en
dc.typeArticleen
dc.contributor.departmentClinical Research Laboratories, Christie Hospital and Holt Radium Institute, Manchester, England.en
dc.identifier.journalSeminars in Arthritis and Rheumatismen
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