2.50
Hdl Handle:
http://hdl.handle.net/10541/109434
Title:
Understanding FOXO, new views on old transcription factors.
Authors:
Zanella, Fabian; Link, Wolfgang; Carnero, Amancio
Abstract:
FOXO proteins are evolutionarily conserved transcription factors implicated in several fundamental cellular processes, functioning as end-point for transcriptional programs involved in apoptosis, stress response and longevity. Abrogation of FOXO function is very frequent in human cancer, therefore the mechanisms of regulation of the FOXO proteins are receiving increasing attention in cancer research. The FOXO proteins integrate regulatory inputs from a variety of upstream signaling pathways, most importantly in response to growth factor and stress signalling. Recently, FOXO factors have been established as tumor suppressors, promoting the transcription of pro-apoptotic molecules like FasL and Bim when the PI3K/Akt pathway is downregulated due to nutrient or serum starvation and cellular stress. Therefore, understanding the modulation of FOXO transcription factors will allow the design of new compounds with antitumor potential.
Affiliation:
Experimental Therapeutics programme, Spanish National Cancer Research Centre, Madrid, Spain.
Citation:
Understanding FOXO, new views on old transcription factors. 2010, 10 (2):135-46 Curr Cancer Drug Targets
Journal:
Current Cancer Drug Targets
Issue Date:
1-Mar-2010
URI:
http://hdl.handle.net/10541/109434
PubMed ID:
20088800
Type:
Article
Language:
en
ISSN:
1873-5576
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorZanella, Fabianen
dc.contributor.authorLink, Wolfgangen
dc.contributor.authorCarnero, Amancioen
dc.date.accessioned2010-08-10T15:45:05Z-
dc.date.available2010-08-10T15:45:05Z-
dc.date.issued2010-03-01-
dc.identifier.citationUnderstanding FOXO, new views on old transcription factors. 2010, 10 (2):135-46 Curr Cancer Drug Targetsen
dc.identifier.issn1873-5576-
dc.identifier.pmid20088800-
dc.identifier.urihttp://hdl.handle.net/10541/109434-
dc.description.abstractFOXO proteins are evolutionarily conserved transcription factors implicated in several fundamental cellular processes, functioning as end-point for transcriptional programs involved in apoptosis, stress response and longevity. Abrogation of FOXO function is very frequent in human cancer, therefore the mechanisms of regulation of the FOXO proteins are receiving increasing attention in cancer research. The FOXO proteins integrate regulatory inputs from a variety of upstream signaling pathways, most importantly in response to growth factor and stress signalling. Recently, FOXO factors have been established as tumor suppressors, promoting the transcription of pro-apoptotic molecules like FasL and Bim when the PI3K/Akt pathway is downregulated due to nutrient or serum starvation and cellular stress. Therefore, understanding the modulation of FOXO transcription factors will allow the design of new compounds with antitumor potential.en
dc.language.isoenen
dc.subjectCanceren
dc.subject.meshAging-
dc.subject.meshAnimals-
dc.subject.meshApoptosis-
dc.subject.meshCell Cycle-
dc.subject.meshForkhead Transcription Factors-
dc.subject.meshHumans-
dc.subject.meshNeoplasms-
dc.subject.meshOxidative Stress-
dc.subject.meshSignal Transduction-
dc.subject.meshTranscription Factors-
dc.titleUnderstanding FOXO, new views on old transcription factors.en
dc.typeArticleen
dc.contributor.departmentExperimental Therapeutics programme, Spanish National Cancer Research Centre, Madrid, Spain.en
dc.identifier.journalCurrent Cancer Drug Targetsen

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