GH/IGF-I regulation in obesity--mechanisms and practical consequences in children and adults.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109361
Title:
GH/IGF-I regulation in obesity--mechanisms and practical consequences in children and adults.
Authors:
Kreitschmann-Andermahr, Ilonka; Suarez, Pablo; Jennings, Rachel; Evers, Nina; Brabant, Georg E
Abstract:
Growth hormone (GH) secretion in children and adults is profoundly, but reversibly, suppressed in obesity. Since GH deficiency leads to increased fat mass, differentiation of both conditions remains challenging. Here we review the known and still speculative mechanisms underlying the inhibitory effects of obesity on GH secretion including peripheral factors like IGF-I and insulin, as well as central hypothalamic/pituitary modulators. We further discuss the basis of current testing for GH deficiency in obesity and the validity of the various provocative tests in overweight subjects.
Affiliation:
Department of Endocrinology, Christie Hospital, Manchester, UK.
Citation:
GH/IGF-I regulation in obesity--mechanisms and practical consequences in children and adults. 2010, 73 (3):153-60 Horm Res Paediatr
Journal:
Hormone Research in Pædiatrics
Issue Date:
2010
URI:
http://hdl.handle.net/10541/109361
DOI:
10.1159/000284355
PubMed ID:
20197666
Type:
Article
Language:
en
ISSN:
1663-2826
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorKreitschmann-Andermahr, Ilonkaen
dc.contributor.authorSuarez, Pabloen
dc.contributor.authorJennings, Rachelen
dc.contributor.authorEvers, Ninaen
dc.contributor.authorBrabant, Georg Een
dc.date.accessioned2010-08-10T09:54:52Z-
dc.date.available2010-08-10T09:54:52Z-
dc.date.issued2010-
dc.identifier.citationGH/IGF-I regulation in obesity--mechanisms and practical consequences in children and adults. 2010, 73 (3):153-60 Horm Res Paediatren
dc.identifier.issn1663-2826-
dc.identifier.pmid20197666-
dc.identifier.doi10.1159/000284355-
dc.identifier.urihttp://hdl.handle.net/10541/109361-
dc.description.abstractGrowth hormone (GH) secretion in children and adults is profoundly, but reversibly, suppressed in obesity. Since GH deficiency leads to increased fat mass, differentiation of both conditions remains challenging. Here we review the known and still speculative mechanisms underlying the inhibitory effects of obesity on GH secretion including peripheral factors like IGF-I and insulin, as well as central hypothalamic/pituitary modulators. We further discuss the basis of current testing for GH deficiency in obesity and the validity of the various provocative tests in overweight subjects.en
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshArginine-
dc.subject.meshChild-
dc.subject.meshFatty Acids, Nonesterified-
dc.subject.meshFemale-
dc.subject.meshGhrelin-
dc.subject.meshHuman Growth Hormone-
dc.subject.meshHumans-
dc.subject.meshInsulin-
dc.subject.meshInsulin-Like Growth Factor I-
dc.subject.meshMale-
dc.subject.meshObesity-
dc.subject.meshReproducibility of Results-
dc.titleGH/IGF-I regulation in obesity--mechanisms and practical consequences in children and adults.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital, Manchester, UK.en
dc.identifier.journalHormone Research in Pædiatricsen
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