Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109342
Title:
Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression.
Authors:
Shimoda, Masayuki; Mellody, Kieran T; Orimo, Akira
Abstract:
Tumours are highly complex tissues composed of carcinoma cells and surrounding stroma, which is constructed by various different types of mesenchymal cells and an extracellular matrix (ECM). Carcinoma-associated fibroblasts (CAFs), which consist of both fibroblasts and myofibroblasts, are frequently observed in the stroma of human carcinomas, and their presence in large numbers is often associated with the development of high-grade malignancies and poor prognoses. Moreover, in human tumour xenograft models, CAFs extracted from the tumour are more capable of promoting tumour growth through their interactions with carcinoma cells when compared to those isolated from non-cancerous stroma. Taken together, these observations strongly suggest that CAFs actively contribute to tumour progression. In this review we highlight the emerging roles of these cells in promoting tumourigenesis, and we discuss the molecular mechanisms underlying their tumour-promoting capabilities and their cellular origin.
Affiliation:
Department of Pathology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Citation:
Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression. 2010, 21 (1):19-25 Semin. Cell Dev. Biol.
Journal:
Seminars in Cell & Developmental Biology
Issue Date:
Feb-2010
URI:
http://hdl.handle.net/10541/109342
DOI:
10.1016/j.semcdb.2009.10.002
PubMed ID:
19857592
Type:
Article
Language:
en
ISSN:
1096-3634
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorShimoda, Masayukien
dc.contributor.authorMellody, Kieran Ten
dc.contributor.authorOrimo, Akiraen
dc.date.accessioned2010-08-09T15:44:39Z-
dc.date.available2010-08-09T15:44:39Z-
dc.date.issued2010-02-
dc.identifier.citationCarcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression. 2010, 21 (1):19-25 Semin. Cell Dev. Biol.en
dc.identifier.issn1096-3634-
dc.identifier.pmid19857592-
dc.identifier.doi10.1016/j.semcdb.2009.10.002-
dc.identifier.urihttp://hdl.handle.net/10541/109342-
dc.description.abstractTumours are highly complex tissues composed of carcinoma cells and surrounding stroma, which is constructed by various different types of mesenchymal cells and an extracellular matrix (ECM). Carcinoma-associated fibroblasts (CAFs), which consist of both fibroblasts and myofibroblasts, are frequently observed in the stroma of human carcinomas, and their presence in large numbers is often associated with the development of high-grade malignancies and poor prognoses. Moreover, in human tumour xenograft models, CAFs extracted from the tumour are more capable of promoting tumour growth through their interactions with carcinoma cells when compared to those isolated from non-cancerous stroma. Taken together, these observations strongly suggest that CAFs actively contribute to tumour progression. In this review we highlight the emerging roles of these cells in promoting tumourigenesis, and we discuss the molecular mechanisms underlying their tumour-promoting capabilities and their cellular origin.en
dc.language.isoenen
dc.subjectCanceren
dc.subjectCanerous Cell Transformationen
dc.subjectCancer Transplantationen
dc.subject.meshAnimals-
dc.subject.meshCarcinoma-
dc.subject.meshCell Transformation, Neoplastic-
dc.subject.meshDisease Progression-
dc.subject.meshEpigenesis, Genetic-
dc.subject.meshFibroblasts-
dc.subject.meshHumans-
dc.subject.meshNeoplasm Transplantation-
dc.subject.meshNeoplasms-
dc.subject.meshTransplantation, Heterologous-
dc.titleCarcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.en
dc.identifier.journalSeminars in Cell & Developmental Biologyen
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