2.50
Hdl Handle:
http://hdl.handle.net/10541/109306
Title:
PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions.
Authors:
Van den Bout, Iman; Divecha, Nullin
Abstract:
It has long been known that phosphoinositides are present in cellular membranes, but only in the past four decades has our understanding of their importance for proper cell function advanced significantly. Key to determining the biological roles of phosphoinositides is understanding the enzymes involved in their metabolism. Although many such enzymes have now been identified, there is still much to learn about their cellular functions. Phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) are a group of kinases that catalyse the production of phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P(2)]. As well as being a substrate for the enzymes phospholipase C (PLC) and phosphatidylinositol 3-kinase (PI3K), PtdIns(4,5)P(2) acts as a second messenger in its own right, influencing a variety of cellular processes. In this Commentary, we review how PIP5Ks are modulated to achieve regulated PtdIns(4,5)P(2) production, and discuss the role of these proteins in different cellular processes.
Affiliation:
Inositide Laboratory, Paterson Institute for Cancer Research, Wilmslow Road, Manchester M20 4BX, UK. ivbout@picr.man.ac.uk
Citation:
PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions. 2009, 122 (Pt 21):3837-50 J. Cell. Sci.
Journal:
Journal of Cell Science
Issue Date:
1-Nov-2009
URI:
http://hdl.handle.net/10541/109306
DOI:
10.1242/jcs.056127
PubMed ID:
19889969
Type:
Article
Language:
en
ISSN:
1477-9137
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorVan den Bout, Imanen
dc.contributor.authorDivecha, Nullinen
dc.date.accessioned2010-08-09T15:29:31Z-
dc.date.available2010-08-09T15:29:31Z-
dc.date.issued2009-11-01-
dc.identifier.citationPIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions. 2009, 122 (Pt 21):3837-50 J. Cell. Sci.en
dc.identifier.issn1477-9137-
dc.identifier.pmid19889969-
dc.identifier.doi10.1242/jcs.056127-
dc.identifier.urihttp://hdl.handle.net/10541/109306-
dc.description.abstractIt has long been known that phosphoinositides are present in cellular membranes, but only in the past four decades has our understanding of their importance for proper cell function advanced significantly. Key to determining the biological roles of phosphoinositides is understanding the enzymes involved in their metabolism. Although many such enzymes have now been identified, there is still much to learn about their cellular functions. Phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) are a group of kinases that catalyse the production of phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P(2)]. As well as being a substrate for the enzymes phospholipase C (PLC) and phosphatidylinositol 3-kinase (PI3K), PtdIns(4,5)P(2) acts as a second messenger in its own right, influencing a variety of cellular processes. In this Commentary, we review how PIP5Ks are modulated to achieve regulated PtdIns(4,5)P(2) production, and discuss the role of these proteins in different cellular processes.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshGene Expression Regulation, Enzymologic-
dc.subject.meshHumans-
dc.subject.meshMultigene Family-
dc.subject.meshPhosphatidylinositol 4,5-Diphosphate-
dc.subject.meshPhosphotransferases (Alcohol Group Acceptor)-
dc.titlePIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions.en
dc.typeArticleen
dc.contributor.departmentInositide Laboratory, Paterson Institute for Cancer Research, Wilmslow Road, Manchester M20 4BX, UK. ivbout@picr.man.ac.uken
dc.identifier.journalJournal of Cell Scienceen

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