2.50
Hdl Handle:
http://hdl.handle.net/10541/109285
Title:
Dosimetry audit for a multi-centre IMRT head and neck trial.
Authors:
Clark, Catharine H; Hansen, Vibeke Nordmark; Chantler, Hannah; Edwards, Craig; James, Hayley V; Webster, Gareth J; Miles, Elizabeth; Guerrero Urbano, M Teresa; Bhide, Shree A; Bidmead, A Margaret; Nutting, Christoper M
Abstract:
BACKGROUND AND PURPOSE: PARSPORT was a multi-centre randomised trial in the UK which compared Intensity-Modulated Radiotherapy (IMRT) and conventional radiotherapy (CRT) for patients with head and neck cancer. The dosimetry audit goals were to verify the plan delivery in participating centres, ascertain what tolerances were suitable for head and neck IMRT trials and develop an IMRT credentialing program. MATERIALS AND METHODS: Centres enrolling patients underwent rigorous quality assurance before joining the trial. Following this each centre was visited for a dosimetry audit, which consisted of treatment planning system tests, fluence verification films, combined field films and dose point measurements. RESULTS: Mean dose point measurements were made at six centres. For the primary planning target volume (PTV) the differences with the planned values for the IMRT and CRT arms were -0.6% (1.8% to -2.4%) and 0.7% (2.0% to -0.9%), respectively. Ninety-four percent of the IMRT fluence films for individual fields passed gamma criterion of 3%/3mm and 75% of the films for combined fields passed gamma criterion 4%/3mm (no significant difference between dynamic delivery and step and shoot delivery). CONCLUSIONS: This audit suggests that a 3% tolerance could be applied for PTV point doses. For dose distributions tolerances of 3%/3mm on individual fields and 4%/3mm for combined fields are proposed for multi-centre head and neck IMRT trials.
Affiliation:
Department of Physics, Royal Marsden NHS Foundation Trust, London, UK. catharine.clark@rmh.nhs.uk
Citation:
Dosimetry audit for a multi-centre IMRT head and neck trial. 2009, 93 (1):102-8 Radiother Oncol
Journal:
Radiotherapy and Oncology
Issue Date:
Oct-2009
URI:
http://hdl.handle.net/10541/109285
DOI:
10.1016/j.radonc.2009.04.025
PubMed ID:
19596158
Type:
Article
Language:
en
ISSN:
1879-0887
Appears in Collections:
All Christie Publications ; Christie Medical Physics and Engineering Research

Full metadata record

DC FieldValue Language
dc.contributor.authorClark, Catharine Hen
dc.contributor.authorHansen, Vibeke Nordmarken
dc.contributor.authorChantler, Hannahen
dc.contributor.authorEdwards, Craigen
dc.contributor.authorJames, Hayley Ven
dc.contributor.authorWebster, Gareth Jen
dc.contributor.authorMiles, Elizabethen
dc.contributor.authorGuerrero Urbano, M Teresaen
dc.contributor.authorBhide, Shree Aen
dc.contributor.authorBidmead, A Margareten
dc.contributor.authorNutting, Christoper Men
dc.date.accessioned2010-08-09T12:27:29Z-
dc.date.available2010-08-09T12:27:29Z-
dc.date.issued2009-10-
dc.identifier.citationDosimetry audit for a multi-centre IMRT head and neck trial. 2009, 93 (1):102-8 Radiother Oncolen
dc.identifier.issn1879-0887-
dc.identifier.pmid19596158-
dc.identifier.doi10.1016/j.radonc.2009.04.025-
dc.identifier.urihttp://hdl.handle.net/10541/109285-
dc.description.abstractBACKGROUND AND PURPOSE: PARSPORT was a multi-centre randomised trial in the UK which compared Intensity-Modulated Radiotherapy (IMRT) and conventional radiotherapy (CRT) for patients with head and neck cancer. The dosimetry audit goals were to verify the plan delivery in participating centres, ascertain what tolerances were suitable for head and neck IMRT trials and develop an IMRT credentialing program. MATERIALS AND METHODS: Centres enrolling patients underwent rigorous quality assurance before joining the trial. Following this each centre was visited for a dosimetry audit, which consisted of treatment planning system tests, fluence verification films, combined field films and dose point measurements. RESULTS: Mean dose point measurements were made at six centres. For the primary planning target volume (PTV) the differences with the planned values for the IMRT and CRT arms were -0.6% (1.8% to -2.4%) and 0.7% (2.0% to -0.9%), respectively. Ninety-four percent of the IMRT fluence films for individual fields passed gamma criterion of 3%/3mm and 75% of the films for combined fields passed gamma criterion 4%/3mm (no significant difference between dynamic delivery and step and shoot delivery). CONCLUSIONS: This audit suggests that a 3% tolerance could be applied for PTV point doses. For dose distributions tolerances of 3%/3mm on individual fields and 4%/3mm for combined fields are proposed for multi-centre head and neck IMRT trials.en
dc.language.isoenen
dc.subjectHead and Neck Canceren
dc.subjectCancer Stagingen
dc.subject.meshAged-
dc.subject.meshCarcinoma, Squamous Cell-
dc.subject.meshDose-Response Relationship, Radiation-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHead and Neck Neoplasms-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMedical Audit-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Staging-
dc.subject.meshProspective Studies-
dc.subject.meshQuality Control-
dc.subject.meshRadiation Tolerance-
dc.subject.meshRadiometry-
dc.subject.meshRadiotherapy Dosage-
dc.subject.meshRadiotherapy Planning, Computer-Assisted-
dc.subject.meshRadiotherapy, Computer-Assisted-
dc.subject.meshRadiotherapy, Intensity-Modulated-
dc.subject.meshRisk Factors-
dc.subject.meshTreatment Outcome-
dc.titleDosimetry audit for a multi-centre IMRT head and neck trial.en
dc.typeArticleen
dc.contributor.departmentDepartment of Physics, Royal Marsden NHS Foundation Trust, London, UK. catharine.clark@rmh.nhs.uken
dc.identifier.journalRadiotherapy and Oncologyen

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