HLA class II antigen expression in human papillomavirus-associated cervical cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109017
Title:
HLA class II antigen expression in human papillomavirus-associated cervical cancer.
Authors:
Glew, Susan S; Duggan-Keen, Margaret F; Cabrera, T; Stern, Peter L
Abstract:
The observation that tumor cells of some neoplasms display major histocompatibility complex (MHC) class II molecules may be of functional significance, influencing the progression of malignancy by allowing the cancer cells to present antigen to the immune system. In the normal cervix, class II molecules are expressed by columnar but not squamous epithelium. The pattern of MHC class II expression in cervical carcinomas has been documented using immunohistochemical methods. Of 53 cervical squamous carcinomas examined for MHC class II expression, only 17% maintained a negative phenotype characteristic of the epithelium from which they were derived, while the remaining tumors exhibited either uniform (45%) or heterogeneous (38%) expression. Tumor areas which were class II positive also express class II associated invariant chain and the adhesion molecules lymphocyte function antigen 3 and intercellular adhesion molecule 1. The DR, DP, and DQ class II MHC subloci are differentially expressed, suggesting independent regulation. There is a trend for tumors with the uniform class II phenotype to predominantly express DR antigen, whereas tumors of the heterogeneous class II phenotype express with equal frequency either DR or DP antigens dominantly. There is no apparent influence of class II status on lymphocyte infiltration of the tumors. The presence of human papillomavirus 16 DNA in the cervical carcinoma specimens was analyzed by Southern blotting of restriction enzyme digested DNA and no correlation between the presence of human papilloma virus and MHC class II expression was found.
Affiliation:
Cancer Research Campaign Department of Immunology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom.
Citation:
HLA class II antigen expression in human papillomavirus-associated cervical cancer. 1992, 52 (14):4009-16 Cancer Res.
Journal:
Cancer Research
Issue Date:
15-Jul-1992
URI:
http://hdl.handle.net/10541/109017
PubMed ID:
1377602
Type:
Article
Language:
en
ISSN:
0008-5472
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorGlew, Susan Sen
dc.contributor.authorDuggan-Keen, Margaret Fen
dc.contributor.authorCabrera, Ten
dc.contributor.authorStern, Peter Len
dc.date.accessioned2010-08-04T09:15:58Z-
dc.date.available2010-08-04T09:15:58Z-
dc.date.issued1992-07-15-
dc.identifier.citationHLA class II antigen expression in human papillomavirus-associated cervical cancer. 1992, 52 (14):4009-16 Cancer Res.en
dc.identifier.issn0008-5472-
dc.identifier.pmid1377602-
dc.identifier.urihttp://hdl.handle.net/10541/109017-
dc.description.abstractThe observation that tumor cells of some neoplasms display major histocompatibility complex (MHC) class II molecules may be of functional significance, influencing the progression of malignancy by allowing the cancer cells to present antigen to the immune system. In the normal cervix, class II molecules are expressed by columnar but not squamous epithelium. The pattern of MHC class II expression in cervical carcinomas has been documented using immunohistochemical methods. Of 53 cervical squamous carcinomas examined for MHC class II expression, only 17% maintained a negative phenotype characteristic of the epithelium from which they were derived, while the remaining tumors exhibited either uniform (45%) or heterogeneous (38%) expression. Tumor areas which were class II positive also express class II associated invariant chain and the adhesion molecules lymphocyte function antigen 3 and intercellular adhesion molecule 1. The DR, DP, and DQ class II MHC subloci are differentially expressed, suggesting independent regulation. There is a trend for tumors with the uniform class II phenotype to predominantly express DR antigen, whereas tumors of the heterogeneous class II phenotype express with equal frequency either DR or DP antigens dominantly. There is no apparent influence of class II status on lymphocyte infiltration of the tumors. The presence of human papillomavirus 16 DNA in the cervical carcinoma specimens was analyzed by Southern blotting of restriction enzyme digested DNA and no correlation between the presence of human papilloma virus and MHC class II expression was found.en
dc.language.isoenen
dc.subjectTumour Virus Infectionsen
dc.subjectUterine Cervical Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAntigens, CD58-
dc.subject.meshAntigens, Surface-
dc.subject.meshCarcinoma, Squamous Cell-
dc.subject.meshCell Adhesion Molecules-
dc.subject.meshCervix Uteri-
dc.subject.meshDNA, Viral-
dc.subject.meshFemale-
dc.subject.meshHLA-DP Antigens-
dc.subject.meshHLA-DQ Antigens-
dc.subject.meshHLA-DR Antigens-
dc.subject.meshHistocompatibility Antigens Class I-
dc.subject.meshHistocompatibility Antigens Class II-
dc.subject.meshHumans-
dc.subject.meshIntercellular Adhesion Molecule-1-
dc.subject.meshLeukocyte Count-
dc.subject.meshLymphocytes, Tumor-Infiltrating-
dc.subject.meshMembrane Glycoproteins-
dc.subject.meshMiddle Aged-
dc.subject.meshPapillomaviridae-
dc.subject.meshPhenotype-
dc.subject.meshTumor Virus Infections-
dc.subject.meshUterine Cervical Neoplasms-
dc.titleHLA class II antigen expression in human papillomavirus-associated cervical cancer.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Department of Immunology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom.en
dc.identifier.journalCancer Researchen

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