The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108996
Title:
The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice.
Authors:
Potten, Christopher S
Abstract:
The crypts of the gastrointestinal mucosa are highly structured and polarised organs with rapid cell proliferation and an hierarchical organisation with relatively few stem cells. These tend to be located at specific positions in the tissue--at the crypt base in the colon and about four cell positions from the base (above the Paneth cells) in the small intestine. A small but constant level of spontaneous cell death occurs in the crypt. The levels of cell death are elevated by small exposures to radiation or cytotoxic drugs. The morphology of the cell death is typical of apoptosis. The maximum yield of cell death following cytotoxic exposure is observed at about 3-6 h after treatment and for many agents the death is characteristically located at the fourth (stem) cell position in the small intestine. The significance and implications of these observations are discussed in relation to the internal screening and programming within damage cells and with respect to tissue homeostatic mechanisms.
Affiliation:
CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK.
Citation:
The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice. 1992, 11 (2):179-95 Cancer Metastasis Rev.
Journal:
Cancer Metastasis Reviews
Issue Date:
Sep-1992
URI:
http://hdl.handle.net/10541/108996
DOI:
10.1007/BF00048063
PubMed ID:
1394796
Type:
Article
Language:
en
ISSN:
0167-7659
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorPotten, Christopher Sen
dc.date.accessioned2010-08-04T09:14:06Z-
dc.date.available2010-08-04T09:14:06Z-
dc.date.issued1992-09-
dc.identifier.citationThe significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice. 1992, 11 (2):179-95 Cancer Metastasis Rev.en
dc.identifier.issn0167-7659-
dc.identifier.pmid1394796-
dc.identifier.doi10.1007/BF00048063-
dc.identifier.urihttp://hdl.handle.net/10541/108996-
dc.description.abstractThe crypts of the gastrointestinal mucosa are highly structured and polarised organs with rapid cell proliferation and an hierarchical organisation with relatively few stem cells. These tend to be located at specific positions in the tissue--at the crypt base in the colon and about four cell positions from the base (above the Paneth cells) in the small intestine. A small but constant level of spontaneous cell death occurs in the crypt. The levels of cell death are elevated by small exposures to radiation or cytotoxic drugs. The morphology of the cell death is typical of apoptosis. The maximum yield of cell death following cytotoxic exposure is observed at about 3-6 h after treatment and for many agents the death is characteristically located at the fourth (stem) cell position in the small intestine. The significance and implications of these observations are discussed in relation to the internal screening and programming within damage cells and with respect to tissue homeostatic mechanisms.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshApoptosis-
dc.subject.meshDNA Damage-
dc.subject.meshGastric Mucosa-
dc.subject.meshIntestinal Mucosa-
dc.subject.meshMice-
dc.subject.meshMutagens-
dc.titleThe significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK.en
dc.identifier.journalCancer Metastasis Reviewsen
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