Involvement of alkylating agents in schistosome-associated bladder cancer: the possible basic mechanisms of induction.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108995
Title:
Involvement of alkylating agents in schistosome-associated bladder cancer: the possible basic mechanisms of induction.
Authors:
Badawi, Alaa F; Mostafa, M H; O'Connor, Peter J
Abstract:
Carcinoma of the urinary bladder is a common malignancy in many tropical and subtropical countries. There is a well documented sequela of chronic urinary schistosomal infection and bladder cancer associated with schistosomiasis is a major cause of morbidity and mortality in the endemic areas. Experimental bladder cancer can be induced in schistosome-infected animals. Multiple factors have been suggested as causative agents in schistosome-associated bladder carcinogenesis and the N-nitroso compounds appear to be of particular importance. These agents have long been suspected to play a major role in the aetiology of a variety of human cancers. A model for the induction of bladder cancer associated with schistosomiasis is proposed which takes into account the interrelationships between different factors resulting from the infection, especially the role of alkylating agents that can contribute to the induction of this neoplasm.
Affiliation:
Department of Environmental Studies, Alexandria University, Egypt.
Citation:
Involvement of alkylating agents in schistosome-associated bladder cancer: the possible basic mechanisms of induction. 1992, 63 (3):171-88 Cancer Lett.
Journal:
Cancer Letters
Issue Date:
30-Apr-1992
URI:
http://hdl.handle.net/10541/108995
DOI:
10.1016/0304-3835(92)90259-X
PubMed ID:
1576589
Type:
Article
Language:
en
ISSN:
0304-3835
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorBadawi, Alaa Fen
dc.contributor.authorMostafa, M Hen
dc.contributor.authorO'Connor, Peter Jen
dc.date.accessioned2010-08-04T09:12:32Z-
dc.date.available2010-08-04T09:12:32Z-
dc.date.issued1992-04-30-
dc.identifier.citationInvolvement of alkylating agents in schistosome-associated bladder cancer: the possible basic mechanisms of induction. 1992, 63 (3):171-88 Cancer Lett.en
dc.identifier.issn0304-3835-
dc.identifier.pmid1576589-
dc.identifier.doi10.1016/0304-3835(92)90259-X-
dc.identifier.urihttp://hdl.handle.net/10541/108995-
dc.description.abstractCarcinoma of the urinary bladder is a common malignancy in many tropical and subtropical countries. There is a well documented sequela of chronic urinary schistosomal infection and bladder cancer associated with schistosomiasis is a major cause of morbidity and mortality in the endemic areas. Experimental bladder cancer can be induced in schistosome-infected animals. Multiple factors have been suggested as causative agents in schistosome-associated bladder carcinogenesis and the N-nitroso compounds appear to be of particular importance. These agents have long been suspected to play a major role in the aetiology of a variety of human cancers. A model for the induction of bladder cancer associated with schistosomiasis is proposed which takes into account the interrelationships between different factors resulting from the infection, especially the role of alkylating agents that can contribute to the induction of this neoplasm.en
dc.language.isoenen
dc.subjectUrinary Bladder Canceren
dc.subject.meshAlkylating Agents-
dc.subject.meshDNA Damage-
dc.subject.meshDNA Repair-
dc.subject.meshHumans-
dc.subject.meshMethyltransferases-
dc.subject.meshNitrosamines-
dc.subject.meshNitroso Compounds-
dc.subject.meshO(6)-Methylguanine-DNA Methyltransferase-
dc.subject.meshSchistosomiasis-
dc.subject.meshUrinary Bladder Neoplasms-
dc.titleInvolvement of alkylating agents in schistosome-associated bladder cancer: the possible basic mechanisms of induction.en
dc.typeArticleen
dc.contributor.departmentDepartment of Environmental Studies, Alexandria University, Egypt.en
dc.identifier.journalCancer Lettersen
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