The clonogen content of murine intestinal crypts: dependence on radiation dose used in its determination.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108928
Title:
The clonogen content of murine intestinal crypts: dependence on radiation dose used in its determination.
Authors:
Hendry, Jolyon H; Roberts, Stephen A; Potten, Christopher S
Abstract:
The number of colony-forming (clonogenic) cells in each of the crypts in mouse small intestine was deduced using a two-dose irradiation technique. The number was 7.5 +/- 0.8 cells using two equal doses each less than 9 Gy and 38 +/- 7 cells using 9 Gy or more per dose. The significant dose dependence could not be accounted for by considerations of intra- or intercrypt variability, or by the factor introduced to correct the sampling frequency for the influence of crypt size. The results suggest that more colony-forming cells may be recruited when the injury is more severe.
Affiliation:
Cancer Research Campaign Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, United Kingdom.
Citation:
The clonogen content of murine intestinal crypts: dependence on radiation dose used in its determination. 1992, 132 (1):115-9 Radiat. Res.
Journal:
Radiation Research
Issue Date:
Oct-1992
URI:
http://hdl.handle.net/10541/108928
PubMed ID:
1410267
Type:
Article
Language:
en
ISSN:
0033-7587
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHendry, Jolyon Hen
dc.contributor.authorRoberts, Stephen Aen
dc.contributor.authorPotten, Christopher Sen
dc.date.accessioned2010-08-03T11:54:50Z-
dc.date.available2010-08-03T11:54:50Z-
dc.date.issued1992-10-
dc.identifier.citationThe clonogen content of murine intestinal crypts: dependence on radiation dose used in its determination. 1992, 132 (1):115-9 Radiat. Res.en
dc.identifier.issn0033-7587-
dc.identifier.pmid1410267-
dc.identifier.urihttp://hdl.handle.net/10541/108928-
dc.description.abstractThe number of colony-forming (clonogenic) cells in each of the crypts in mouse small intestine was deduced using a two-dose irradiation technique. The number was 7.5 +/- 0.8 cells using two equal doses each less than 9 Gy and 38 +/- 7 cells using 9 Gy or more per dose. The significant dose dependence could not be accounted for by considerations of intra- or intercrypt variability, or by the factor introduced to correct the sampling frequency for the influence of crypt size. The results suggest that more colony-forming cells may be recruited when the injury is more severe.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshColony-Forming Units Assay-
dc.subject.meshDose-Response Relationship, Radiation-
dc.subject.meshIntestine, Small-
dc.subject.meshMale-
dc.subject.meshMice-
dc.subject.meshStem Cells-
dc.titleThe clonogen content of murine intestinal crypts: dependence on radiation dose used in its determination.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, United Kingdom.en
dc.identifier.journalRadiation Researchen
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