Heparan sulphate in the binding and activation of basic fibroblast growth factor.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108925
Title:
Heparan sulphate in the binding and activation of basic fibroblast growth factor.
Authors:
Gallagher, John T; Turnbull, Jeremy E
Abstract:
Heparan sulphate proteoglycans (HSPGs) are widely distributed in animal tissues, but their most prominent locations are cell surface membranes and basement membranes. Their influence on various fundamental aspects of cell behaviour (e.g. cell adhesion, growth and morphogenesis) are dependent on the specific binding properties of the heparan sulphate (HS) chains. These polysaccharides are complex structures in which N-sulphated glucosamine and ester sulphate groups tend to be clustered in discrete regions of the chain separated by sequences enriched in N-acetylglucosamine residues, but with a low sulphate concentration. The sulphated domains contain the sugar residue sequences for interaction with specific proteins essential for HS function. In this review, we describe the plasma membrane HSPGs and their role in regulating the activity of basic fibroblast growth factor (bFGF).
Affiliation:
Department of Medical Oncology, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Heparan sulphate in the binding and activation of basic fibroblast growth factor. 1992, 2 (6):523-8 Glycobiology
Journal:
Glycobiology
Issue Date:
Dec-1992
URI:
http://hdl.handle.net/10541/108925
DOI:
10.1093/glycob/2.6.523
PubMed ID:
1472758
Type:
Article
Language:
en
ISSN:
0959-6658
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorGallagher, John Ten
dc.contributor.authorTurnbull, Jeremy Een
dc.date.accessioned2010-08-03T11:22:33Z-
dc.date.available2010-08-03T11:22:33Z-
dc.date.issued1992-12-
dc.identifier.citationHeparan sulphate in the binding and activation of basic fibroblast growth factor. 1992, 2 (6):523-8 Glycobiologyen
dc.identifier.issn0959-6658-
dc.identifier.pmid1472758-
dc.identifier.doi10.1093/glycob/2.6.523-
dc.identifier.urihttp://hdl.handle.net/10541/108925-
dc.description.abstractHeparan sulphate proteoglycans (HSPGs) are widely distributed in animal tissues, but their most prominent locations are cell surface membranes and basement membranes. Their influence on various fundamental aspects of cell behaviour (e.g. cell adhesion, growth and morphogenesis) are dependent on the specific binding properties of the heparan sulphate (HS) chains. These polysaccharides are complex structures in which N-sulphated glucosamine and ester sulphate groups tend to be clustered in discrete regions of the chain separated by sequences enriched in N-acetylglucosamine residues, but with a low sulphate concentration. The sulphated domains contain the sugar residue sequences for interaction with specific proteins essential for HS function. In this review, we describe the plasma membrane HSPGs and their role in regulating the activity of basic fibroblast growth factor (bFGF).en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshBinding Sites-
dc.subject.meshCarbohydrate Sequence-
dc.subject.meshCell Membrane-
dc.subject.meshFibroblast Growth Factor 2-
dc.subject.meshHeparan Sulfate Proteoglycans-
dc.subject.meshHeparitin Sulfate-
dc.subject.meshHumans-
dc.subject.meshMolecular Sequence Data-
dc.subject.meshProteoglycans-
dc.titleHeparan sulphate in the binding and activation of basic fibroblast growth factor.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Oncology, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalGlycobiologyen
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