Dimethanesulphonate esters in receptor mapping studies. 2. Antitumour activities of alkyl and alkoxy dimethanesulphonates substituted on a benzene nucleus.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108922
Title:
Dimethanesulphonate esters in receptor mapping studies. 2. Antitumour activities of alkyl and alkoxy dimethanesulphonates substituted on a benzene nucleus.
Authors:
Hadfield, John A; Fox, Brian W; Caffrey, Robert
Abstract:
The antitumour activities of 15 novel aromatic dimethanesulphonate esters were studied. Several alkyl and alkoxy compounds have shown good antitumour activity whilst similar isomers have proved ineffective as antitumour agents. These differences in activity have been correlated with the length of the sidechain substituents and their relative flexibilities.
Affiliation:
Department of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital Trust, Withington, Manchester, UK.
Citation:
Dimethanesulphonate esters in receptor mapping studies. 2. Antitumour activities of alkyl and alkoxy dimethanesulphonates substituted on a benzene nucleus. 1992, 7 (3):263-75 Anticancer Drug Des.
Journal:
Anti-Cancer Drug Design
Issue Date:
Jun-1992
URI:
http://hdl.handle.net/10541/108922
PubMed ID:
1610483
Type:
Article
Language:
en
ISSN:
0266-9536
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHadfield, John Aen
dc.contributor.authorFox, Brian Wen
dc.contributor.authorCaffrey, Roberten
dc.date.accessioned2010-08-03T11:07:06Z-
dc.date.available2010-08-03T11:07:06Z-
dc.date.issued1992-06-
dc.identifier.citationDimethanesulphonate esters in receptor mapping studies. 2. Antitumour activities of alkyl and alkoxy dimethanesulphonates substituted on a benzene nucleus. 1992, 7 (3):263-75 Anticancer Drug Des.en
dc.identifier.issn0266-9536-
dc.identifier.pmid1610483-
dc.identifier.urihttp://hdl.handle.net/10541/108922-
dc.description.abstractThe antitumour activities of 15 novel aromatic dimethanesulphonate esters were studied. Several alkyl and alkoxy compounds have shown good antitumour activity whilst similar isomers have proved ineffective as antitumour agents. These differences in activity have been correlated with the length of the sidechain substituents and their relative flexibilities.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshBenzene-
dc.subject.meshDrug Design-
dc.subject.meshMethyl Methanesulfonate-
dc.subject.meshRats-
dc.subject.meshReceptors, Drug-
dc.subject.meshStructure-Activity Relationship-
dc.titleDimethanesulphonate esters in receptor mapping studies. 2. Antitumour activities of alkyl and alkoxy dimethanesulphonates substituted on a benzene nucleus.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital Trust, Withington, Manchester, UK.en
dc.identifier.journalAnti-Cancer Drug Designen
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