2.50
Hdl Handle:
http://hdl.handle.net/10541/108913
Title:
Human cord blood: a source of transplantable stem cells?
Authors:
Hows, Jill M; Marsh, Judith C W; Bradley, B A; Luft, Thomas; Coutinho, Lucia H; Testa, Nydia G; Dexter, T Michael
Abstract:
In a preliminary study we have shown that optimally collected human umbilical cord (HUC) blood cells grow significantly better in long term cultures (LTC) than normal adult marrow cells (NBM) p = 0.0007. The LTC findings are supported by the observation in clonogenic assay that a similar number of GM-CFC colonies can be grown from HUC blood and NBM mononuclear cells (MNC). Also there is a trend towards a higher proportion of primitive erythroid (BFU-E) and primitive megakaryocyte colonies (MK-CFC containing greater than 20 cells) in HUC blood compared with NBM. We suggest that further work on the feasibility of a HLA typed, cryopreserved HUC blood bank as a source of unrelated haemopoietic 'stem' cells for clinical transplantation is indicated.
Affiliation:
Kay Kendall Laboratory, Paterson Institute, Cancer Research Campaign, Manchester, UK.
Citation:
Human cord blood: a source of transplantable stem cells? 1992, 9 Suppl 1:105-8 Bone Marrow Transplant.
Journal:
Bone Marrow Transplantation
Issue Date:
1992
URI:
http://hdl.handle.net/10541/108913
PubMed ID:
1354517
Type:
Article
Language:
en
ISSN:
0268-3369
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHows, Jill Men
dc.contributor.authorMarsh, Judith C Wen
dc.contributor.authorBradley, B Aen
dc.contributor.authorLuft, Thomasen
dc.contributor.authorCoutinho, Lucia Hen
dc.contributor.authorTesta, Nydia Gen
dc.contributor.authorDexter, T Michaelen
dc.date.accessioned2010-08-03T10:23:08Z-
dc.date.available2010-08-03T10:23:08Z-
dc.date.issued1992-
dc.identifier.citationHuman cord blood: a source of transplantable stem cells? 1992, 9 Suppl 1:105-8 Bone Marrow Transplant.en
dc.identifier.issn0268-3369-
dc.identifier.pmid1354517-
dc.identifier.urihttp://hdl.handle.net/10541/108913-
dc.description.abstractIn a preliminary study we have shown that optimally collected human umbilical cord (HUC) blood cells grow significantly better in long term cultures (LTC) than normal adult marrow cells (NBM) p = 0.0007. The LTC findings are supported by the observation in clonogenic assay that a similar number of GM-CFC colonies can be grown from HUC blood and NBM mononuclear cells (MNC). Also there is a trend towards a higher proportion of primitive erythroid (BFU-E) and primitive megakaryocyte colonies (MK-CFC containing greater than 20 cells) in HUC blood compared with NBM. We suggest that further work on the feasibility of a HLA typed, cryopreserved HUC blood bank as a source of unrelated haemopoietic 'stem' cells for clinical transplantation is indicated.en
dc.language.isoenen
dc.subjectFoetal Blooden
dc.subjectFoetal Tissue Transplantationen
dc.subjectHaematopoietic Stem Cell Transplantationen
dc.subjectHaematopoietic Stem Cellsen
dc.subject.meshBlood Cell Count-
dc.subject.meshBlood Specimen Collection-
dc.subject.meshCells, Cultured-
dc.subject.meshColony-Forming Units Assay-
dc.subject.meshFeasibility Studies-
dc.subject.meshFetal Blood-
dc.subject.meshFetal Tissue Transplantation-
dc.subject.meshHematopoietic Stem Cell Transplantation-
dc.subject.meshHematopoietic Stem Cells-
dc.subject.meshHumans-
dc.subject.meshInfant, Newborn-
dc.titleHuman cord blood: a source of transplantable stem cells?en
dc.typeArticleen
dc.contributor.departmentKay Kendall Laboratory, Paterson Institute, Cancer Research Campaign, Manchester, UK.en
dc.identifier.journalBone Marrow Transplantationen

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