2.50
Hdl Handle:
http://hdl.handle.net/10541/108906
Title:
Cell adhesion in the stromal regulation of haemopoiesis.
Authors:
Clark, B R; Gallagher, John T; Dexter, T Michael
Abstract:
Haemopoiesis occurs in close physical contact with elements of the bone marrow stroma. This review examines some adhesion molecules which are expressed in haemopoietic environments. These molecules may act to maintain cell contact between haemopoietic progenitors and the cellular and extracellular matrix elements of the marrow stroma. A review is undertaken of several families of adhesion molecules and their ligands, including integrins, CD44, LEC-CAMs, CAMs and variant glycosylation patterns expressed by haemopoietic cells. Both CD44 and integrin receptors have been implicated in mediating important cellular interactions within the haemopoietic system and the significance of these and other molecules in haemopoiesis is discussed.
Citation:
Cell adhesion in the stromal regulation of haemopoiesis. 1992, 5 (3):619-52 Baillieres Clin. Haematol.
Journal:
Baillière's Clinical Haematology
Issue Date:
Jul-1992
URI:
http://hdl.handle.net/10541/108906
PubMed ID:
1457965
Type:
Article
Language:
en
ISSN:
0950-3536
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorClark, B Ren
dc.contributor.authorGallagher, John Ten
dc.contributor.authorDexter, T Michaelen
dc.date.accessioned2010-08-03T10:47:17Z-
dc.date.available2010-08-03T10:47:17Z-
dc.date.issued1992-07-
dc.identifier.citationCell adhesion in the stromal regulation of haemopoiesis. 1992, 5 (3):619-52 Baillieres Clin. Haematol.en
dc.identifier.issn0950-3536-
dc.identifier.pmid1457965-
dc.identifier.urihttp://hdl.handle.net/10541/108906-
dc.description.abstractHaemopoiesis occurs in close physical contact with elements of the bone marrow stroma. This review examines some adhesion molecules which are expressed in haemopoietic environments. These molecules may act to maintain cell contact between haemopoietic progenitors and the cellular and extracellular matrix elements of the marrow stroma. A review is undertaken of several families of adhesion molecules and their ligands, including integrins, CD44, LEC-CAMs, CAMs and variant glycosylation patterns expressed by haemopoietic cells. Both CD44 and integrin receptors have been implicated in mediating important cellular interactions within the haemopoietic system and the significance of these and other molecules in haemopoiesis is discussed.en
dc.language.isoenen
dc.subjectHaematologic Diseasesen
dc.subjectHaematopoiesisen
dc.subjectHaematopoietic Cell Growth Factorsen
dc.subjecthaematopoietic Stem Cellsen
dc.subjectHaematopoietic Systemen
dc.subject.meshAmino Acid Sequence-
dc.subject.meshAnimals-
dc.subject.meshBone Marrow Cells-
dc.subject.meshCell Adhesion Molecules-
dc.subject.meshConnective Tissue-
dc.subject.meshExtracellular Matrix-
dc.subject.meshHematologic Diseases-
dc.subject.meshHematopoiesis-
dc.subject.meshHematopoietic Cell Growth Factors-
dc.subject.meshHematopoietic Stem Cells-
dc.subject.meshHematopoietic System-
dc.subject.meshHumans-
dc.subject.meshIntegrins-
dc.subject.meshLectins-
dc.subject.meshLymphoid Tissue-
dc.subject.meshMice-
dc.subject.meshMice, Mutant Strains-
dc.subject.meshModels, Biological-
dc.subject.meshMolecular Sequence Data-
dc.subject.meshOrgan Culture Techniques-
dc.subject.meshProteoglycans-
dc.subject.meshReceptors, Lymphocyte Homing-
dc.subject.meshVertebrates-
dc.titleCell adhesion in the stromal regulation of haemopoiesis.en
dc.typeArticleen
dc.identifier.journalBaillière's Clinical Haematologyen
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