Detection of EBV DNA in post-nasal space biopsy tissue from asymptomatic EBV-seropositive individuals.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108884
Title:
Detection of EBV DNA in post-nasal space biopsy tissue from asymptomatic EBV-seropositive individuals.
Authors:
Lees, Janice F; Goodeve, A C; Arrand, J E; Ghosh, Anna K; Jones, P H; Arrand, John R
Abstract:
The association between EBV and nasopharyngeal carcinoma (NPC) has been well documented although the precise role of the virus in the genesis of the tumour is not understood. We undertook this study to examine the prevalence of EBV infection in nasopharyngeal tissue obtained from 33 healthy individuals not considered to be at risk of developing NPC. Using polymerase chain amplification (PCR) and in situ hybridization we have identified EBV DNA in 70% (23/33) of the tissues examined. Our data demonstrate that EBV is present at the site of tumour development in the low-risk population and by inference that the virus is also present before the onset of disease in the high-risk group. This survey supports the concept of NPC pathogenesis as a multifactorial process.
Affiliation:
Paterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom.
Citation:
Detection of EBV DNA in post-nasal space biopsy tissue from asymptomatic EBV-seropositive individuals. 1992, 37 (1):30-8 J. Med. Virol.
Journal:
Journal of Medical Virology
Issue Date:
May-1992
URI:
http://hdl.handle.net/10541/108884
DOI:
10.1002/jmv.1890370106
PubMed ID:
1320096
Type:
Article
Language:
en
ISSN:
0146-6615
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorLees, Janice Fen
dc.contributor.authorGoodeve, A Cen
dc.contributor.authorArrand, J Een
dc.contributor.authorGhosh, Anna Ken
dc.contributor.authorJones, P Hen
dc.contributor.authorArrand, John Ren
dc.date.accessioned2010-08-03T08:43:43Z-
dc.date.available2010-08-03T08:43:43Z-
dc.date.issued1992-05-
dc.identifier.citationDetection of EBV DNA in post-nasal space biopsy tissue from asymptomatic EBV-seropositive individuals. 1992, 37 (1):30-8 J. Med. Virol.en
dc.identifier.issn0146-6615-
dc.identifier.pmid1320096-
dc.identifier.doi10.1002/jmv.1890370106-
dc.identifier.urihttp://hdl.handle.net/10541/108884-
dc.description.abstractThe association between EBV and nasopharyngeal carcinoma (NPC) has been well documented although the precise role of the virus in the genesis of the tumour is not understood. We undertook this study to examine the prevalence of EBV infection in nasopharyngeal tissue obtained from 33 healthy individuals not considered to be at risk of developing NPC. Using polymerase chain amplification (PCR) and in situ hybridization we have identified EBV DNA in 70% (23/33) of the tissues examined. Our data demonstrate that EBV is present at the site of tumour development in the low-risk population and by inference that the virus is also present before the onset of disease in the high-risk group. This survey supports the concept of NPC pathogenesis as a multifactorial process.en
dc.language.isoenen
dc.subjectNasopharyngeal Canceren
dc.subjectTumour Virus Infectionsen
dc.subject.meshBase Sequence-
dc.subject.meshBiopsy-
dc.subject.meshDNA, Viral-
dc.subject.meshFemale-
dc.subject.meshHerpesvirus 4, Human-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshMale-
dc.subject.meshMolecular Sequence Data-
dc.subject.meshNasal Cavity-
dc.subject.meshNasopharyngeal Neoplasms-
dc.subject.meshNucleic Acid Hybridization-
dc.subject.meshPolymerase Chain Reaction-
dc.subject.meshSensitivity and Specificity-
dc.subject.meshTumor Virus Infections-
dc.titleDetection of EBV DNA in post-nasal space biopsy tissue from asymptomatic EBV-seropositive individuals.en
dc.typeArticleen
dc.contributor.departmentPaterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom.en
dc.identifier.journalJournal of Medical Virologyen

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