2.50
Hdl Handle:
http://hdl.handle.net/10541/108875
Title:
Erythropoietin and myeloid colony stimulating factors.
Authors:
Cowling, Graham J; Dexter, T Michael
Abstract:
The production of blood cells in the body is controlled by at least 20 polypeptide growth factors. Most of these factors have been cloned and many expressed in bacterial and eukaryotic systems to give biologically active proteins. Currently, these recombinant human proteins are undergoing intensive evaluation for their use in treating primary haemopoietic diseases, or stimulating normal haemopoiesis following drug-, radiation- or virus-induced trauma of the bone marrow. Erythropoietin (EPO) and the myeloid colony stimulating factors (IL-3, G-CSF, GM-CSF and M-CSF) were among the first to be cloned and expressed.
Affiliation:
CRC Department of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Erythropoietin and myeloid colony stimulating factors. 1992, 10 (10):349-57 Trends Biotechnol.
Journal:
Trends in Biotechnology
Issue Date:
Oct-1992
URI:
http://hdl.handle.net/10541/108875
DOI:
10.1016/0167-7799(92)90267-Y
PubMed ID:
1368874
Type:
Article
Language:
en
ISSN:
0167-7799
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorCowling, Graham Jen
dc.contributor.authorDexter, T Michaelen
dc.date.accessioned2010-08-03T08:20:36Z-
dc.date.available2010-08-03T08:20:36Z-
dc.date.issued1992-10-
dc.identifier.citationErythropoietin and myeloid colony stimulating factors. 1992, 10 (10):349-57 Trends Biotechnol.en
dc.identifier.issn0167-7799-
dc.identifier.pmid1368874-
dc.identifier.doi10.1016/0167-7799(92)90267-Y-
dc.identifier.urihttp://hdl.handle.net/10541/108875-
dc.description.abstractThe production of blood cells in the body is controlled by at least 20 polypeptide growth factors. Most of these factors have been cloned and many expressed in bacterial and eukaryotic systems to give biologically active proteins. Currently, these recombinant human proteins are undergoing intensive evaluation for their use in treating primary haemopoietic diseases, or stimulating normal haemopoiesis following drug-, radiation- or virus-induced trauma of the bone marrow. Erythropoietin (EPO) and the myeloid colony stimulating factors (IL-3, G-CSF, GM-CSF and M-CSF) were among the first to be cloned and expressed.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshCloning, Molecular-
dc.subject.meshColony-Stimulating Factors-
dc.subject.meshErythropoietin-
dc.subject.meshGlycosylation-
dc.subject.meshHumans-
dc.subject.meshProtein Conformation-
dc.subject.meshStructure-Activity Relationship-
dc.titleErythropoietin and myeloid colony stimulating factors.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalTrends in Biotechnologyen

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