A study of spindle cell sarcomas showing myofibroblastic differentiation.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108816
Title:
A study of spindle cell sarcomas showing myofibroblastic differentiation.
Authors:
Eyden, Brian P; Banerjee, Saumitra S; Harris, Martin; Mene, A
Abstract:
Five diagnostically problematic spindle cell sarcomas showing invasive character, cellular pleomorphism, and high mitotic rate were studied clinically and histopathologically by conventional light microscopy, immunohistochemistry, and transmission electron microscopy. They showed varied clinical courses, with two causing death within 5 years and three showing recurrent and metastatic behavior. All lacked a clearly defined line of differentiation by conventional light microscopy. By immunohistochemistry, all were positive for vimentin and alpha-smooth muscle actin; in addition, one showed focal S-100 protein positivity, and one stained for desmin. All were cytokeratin negative. By electron microscopy, the great majority of spindle cells in all cases showed abundant rough endoplasmic reticulum and fine myofilaments with focal densities; collagen secretion granules were also found in all cases but in fewer cells. The fine structure and immunophenotype were considered consistent with myofibroblastic differentiation; these tumors, therefore, were designated as sarcomas of myofibroblasts or myofibrosarcomas. The suitability of the alternative diagnostic label of myofibroblastic or matrix-secreting variant of leiomyosarcoma is discussed. Comparisons with similar tumors documented in the literature are drawn.
Affiliation:
Histopathology Department, Christie Hospital and Holt Radium Institute, Manchester, United Kingdom.
Citation:
A study of spindle cell sarcomas showing myofibroblastic differentiation. 15 (4-5):367-78 Ultrastruct Pathol
Journal:
Ultrastructural Pathology
Issue Date:
1991
URI:
http://hdl.handle.net/10541/108816
DOI:
10.3109/01913129109016246
PubMed ID:
1755101
Type:
Article
Language:
en
ISSN:
0191-3123
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorEyden, Brian Pen
dc.contributor.authorBanerjee, Saumitra Sen
dc.contributor.authorHarris, Martinen
dc.contributor.authorMene, Aen
dc.date.accessioned2010-08-02T12:26:16Z-
dc.date.available2010-08-02T12:26:16Z-
dc.date.issued1991-
dc.identifier.citationA study of spindle cell sarcomas showing myofibroblastic differentiation. 15 (4-5):367-78 Ultrastruct Patholen
dc.identifier.issn0191-3123-
dc.identifier.pmid1755101-
dc.identifier.doi10.3109/01913129109016246-
dc.identifier.urihttp://hdl.handle.net/10541/108816-
dc.description.abstractFive diagnostically problematic spindle cell sarcomas showing invasive character, cellular pleomorphism, and high mitotic rate were studied clinically and histopathologically by conventional light microscopy, immunohistochemistry, and transmission electron microscopy. They showed varied clinical courses, with two causing death within 5 years and three showing recurrent and metastatic behavior. All lacked a clearly defined line of differentiation by conventional light microscopy. By immunohistochemistry, all were positive for vimentin and alpha-smooth muscle actin; in addition, one showed focal S-100 protein positivity, and one stained for desmin. All were cytokeratin negative. By electron microscopy, the great majority of spindle cells in all cases showed abundant rough endoplasmic reticulum and fine myofilaments with focal densities; collagen secretion granules were also found in all cases but in fewer cells. The fine structure and immunophenotype were considered consistent with myofibroblastic differentiation; these tumors, therefore, were designated as sarcomas of myofibroblasts or myofibrosarcomas. The suitability of the alternative diagnostic label of myofibroblastic or matrix-secreting variant of leiomyosarcoma is discussed. Comparisons with similar tumors documented in the literature are drawn.en
dc.language.isoenen
dc.subjectCancerous Cell Transformationen
dc.subject.meshActins-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshCell Transformation, Neoplastic-
dc.subject.meshDesmin-
dc.subject.meshFemale-
dc.subject.meshFibroblasts-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshLeiomyosarcoma-
dc.subject.meshMale-
dc.subject.meshMicroscopy, Electron-
dc.subject.meshMiddle Aged-
dc.subject.meshMuscles-
dc.subject.meshS100 Proteins-
dc.subject.meshSarcoma-
dc.subject.meshVimentin-
dc.titleA study of spindle cell sarcomas showing myofibroblastic differentiation.en
dc.typeArticleen
dc.contributor.departmentHistopathology Department, Christie Hospital and Holt Radium Institute, Manchester, United Kingdom.en
dc.identifier.journalUltrastructural Pathologyen

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