Dose dependency of time of onset of radiation-induced growth hormone deficiency.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108814
Title:
Dose dependency of time of onset of radiation-induced growth hormone deficiency.
Authors:
Clayton, Peter E; Shalet, Stephen M
Abstract:
Growth hormone (GH) secretion during insulin-induced hypoglycemia was assessed on 133 occasions in 82 survivors of childhood malignant disease. All had received cranial irradiation with a dose range to the hypothalamic-pituitary axis of 27 to 47.5 Gy (estimated by a schedule of 16 fractions over 3 weeks) and had been tested on one or more occasions between 0.2 and 18.9 years after treatment. Results of one third of the GH tests were defined as normal (GH peak response, greater than 15 mU/L) within the first 5 years, in comparison with 16% after 5 years. Stepwise multiple linear regression analysis showed that dose (p = 0.007) and time from irradiation (p = 0.03), but not age at therapy, had a significant influence on peak GH responses. The late incidence of GH deficiency was similar over the whole dose range (4 of 26 GH test results normal for less than 30 Gy and 4 of 25 normal for greater than or equal to 30 Gy after 5 years), but the speed of onset over the first years was dependent on dose. We conclude that the requirement for GH replacement therapy and the timing of its introduction will be influenced by the dose of irradiation received by the hypothalamic-pituitary axis.
Affiliation:
Department of Endocrinology, Christie Hospital and Holt Radium Institute, Manchester, United Kingdom.
Citation:
Dose dependency of time of onset of radiation-induced growth hormone deficiency. 1991, 118 (2):226-8 J. Pediatr.
Journal:
The Journal of Pediatrics
Issue Date:
Feb-1991
URI:
http://hdl.handle.net/10541/108814
DOI:
10.1016/S0022-3476(05)80487-1
PubMed ID:
1993949
Type:
Article
Language:
en
ISSN:
0022-3476
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorClayton, Peter Een
dc.contributor.authorShalet, Stephen Men
dc.date.accessioned2010-08-02T12:10:38Z-
dc.date.available2010-08-02T12:10:38Z-
dc.date.issued1991-02-
dc.identifier.citationDose dependency of time of onset of radiation-induced growth hormone deficiency. 1991, 118 (2):226-8 J. Pediatr.en
dc.identifier.issn0022-3476-
dc.identifier.pmid1993949-
dc.identifier.doi10.1016/S0022-3476(05)80487-1-
dc.identifier.urihttp://hdl.handle.net/10541/108814-
dc.description.abstractGrowth hormone (GH) secretion during insulin-induced hypoglycemia was assessed on 133 occasions in 82 survivors of childhood malignant disease. All had received cranial irradiation with a dose range to the hypothalamic-pituitary axis of 27 to 47.5 Gy (estimated by a schedule of 16 fractions over 3 weeks) and had been tested on one or more occasions between 0.2 and 18.9 years after treatment. Results of one third of the GH tests were defined as normal (GH peak response, greater than 15 mU/L) within the first 5 years, in comparison with 16% after 5 years. Stepwise multiple linear regression analysis showed that dose (p = 0.007) and time from irradiation (p = 0.03), but not age at therapy, had a significant influence on peak GH responses. The late incidence of GH deficiency was similar over the whole dose range (4 of 26 GH test results normal for less than 30 Gy and 4 of 25 normal for greater than or equal to 30 Gy after 5 years), but the speed of onset over the first years was dependent on dose. We conclude that the requirement for GH replacement therapy and the timing of its introduction will be influenced by the dose of irradiation received by the hypothalamic-pituitary axis.en
dc.language.isoenen
dc.subjectBrain Canceren
dc.subjectLeukaemiaen
dc.subject.meshAdolescent-
dc.subject.meshBrain Neoplasms-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshDose-Response Relationship, Radiation-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshGrowth Hormone-
dc.subject.meshHumans-
dc.subject.meshHypothalamo-Hypophyseal System-
dc.subject.meshInfant-
dc.subject.meshLeukemia-
dc.subject.meshMale-
dc.subject.meshRadiotherapy-
dc.subject.meshRegression Analysis-
dc.titleDose dependency of time of onset of radiation-induced growth hormone deficiency.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital and Holt Radium Institute, Manchester, United Kingdom.en
dc.identifier.journalThe Journal of Pediatricsen
All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.