Filamentous inclusions of unusual composition and architecture in a metastatic tumor showing myoepithelial differentiation.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108808
Title:
Filamentous inclusions of unusual composition and architecture in a metastatic tumor showing myoepithelial differentiation.
Authors:
Eyden, Brian P; Dardick, I; Bishop, Paul
Abstract:
A hyaline/eosinophilic cytoplasmic inclusion is described in a metastatic tumor occurring in the omentum and bowel of a 32-year-old white woman. The tumor was essentially of round cell type; was positive for cytokeratin, actin, and S-100 protein by immunohistochemistry; and showed desmosomes (maculae adherentes), tonofibrils, modestly developed myofilaments with focal densities, and a basal lamina by electron microscopy. It was therefore interpreted as showing myoepithelial differentiation. Nearly all cells possessed a large, rounded cytoplasmic inclusion that was architecturally unusual, consisting of intermediate filaments intermingled with lattices of fine filaments. The inclusions exhibited an additionally unusual immunohistochemical staining for both cytokeratin and actin. A comparison with cases described in the literature is made.
Affiliation:
Department of Histopathology, Christie Hospital, Manchester, United Kingdom.
Citation:
Filamentous inclusions of unusual composition and architecture in a metastatic tumor showing myoepithelial differentiation. 15 (6):663-70 Ultrastruct Pathol
Journal:
Ultrastructural Pathology
Issue Date:
1991
URI:
http://hdl.handle.net/10541/108808
DOI:
10.3109/01913129109023196
PubMed ID:
1665929
Type:
Article
Language:
en
ISSN:
0191-3123
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorEyden, Brian Pen
dc.contributor.authorDardick, Ien
dc.contributor.authorBishop, Paulen
dc.date.accessioned2010-08-02T12:22:04Z-
dc.date.available2010-08-02T12:22:04Z-
dc.date.issued1991-
dc.identifier.citationFilamentous inclusions of unusual composition and architecture in a metastatic tumor showing myoepithelial differentiation. 15 (6):663-70 Ultrastruct Patholen
dc.identifier.issn0191-3123-
dc.identifier.pmid1665929-
dc.identifier.doi10.3109/01913129109023196-
dc.identifier.urihttp://hdl.handle.net/10541/108808-
dc.description.abstractA hyaline/eosinophilic cytoplasmic inclusion is described in a metastatic tumor occurring in the omentum and bowel of a 32-year-old white woman. The tumor was essentially of round cell type; was positive for cytokeratin, actin, and S-100 protein by immunohistochemistry; and showed desmosomes (maculae adherentes), tonofibrils, modestly developed myofilaments with focal densities, and a basal lamina by electron microscopy. It was therefore interpreted as showing myoepithelial differentiation. Nearly all cells possessed a large, rounded cytoplasmic inclusion that was architecturally unusual, consisting of intermediate filaments intermingled with lattices of fine filaments. The inclusions exhibited an additionally unusual immunohistochemical staining for both cytokeratin and actin. A comparison with cases described in the literature is made.en
dc.language.isoenen
dc.subjectIntestinal Canceren
dc.subjectCancer Metastasisen
dc.subject.meshAdult-
dc.subject.meshCarcinoma-
dc.subject.meshCell Differentiation-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshInclusion Bodies-
dc.subject.meshIntestinal Neoplasms-
dc.subject.meshNeoplasm Metastasis-
dc.subject.meshTreatment Outcome-
dc.titleFilamentous inclusions of unusual composition and architecture in a metastatic tumor showing myoepithelial differentiation.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital, Manchester, United Kingdom.en
dc.identifier.journalUltrastructural Pathologyen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.