2.50
Hdl Handle:
http://hdl.handle.net/10541/108806
Title:
Ultrastructure of oesophageal melanocytosis.
Authors:
Yamazaki, K; Ohmori, T; Kumagai, Y; Makuuchi, H; Eyden, Brian P
Abstract:
Four examples of an endoscopically detected oesophageal melanotic lesion were examined by light microscopy, light microscope histochemistry and transmission electron microscopy, and were compared with 13 control samples of normal oesophageal epithelium. By light microscopy, pigmented melanocytes lacking atypia and mitoses were observed amongst the keratinocytes in the basal layer of the oesophageal mucosa. Junctional activity was absent. The mechanism of pigmentation was studied and found to consist of: an increase in the number of melanocytes in the basal layer of the mucosa, an increase in the quantity of melanin in these melanocytes, transfer of melanin from melanocytes to keratinocytes and to macrophages and fibroblasts in the tunica propria. Since all the lesions demonstrated increased numbers of both melanocytes and melanosomes, the term oesophageal melanocytosis rather than melanosis is suggested, to emphasise the essential character of the lesion as a cellular proliferation. The value of sampling these pigmented lesions during endoscopy is emphasised as a means of obtaining well-preserved material for the evaluation of a lesion which some authorities have viewed as a possible precursor for oesophageal malignant melanoma.
Affiliation:
Department of Pathology, School of Medicine, Keio University, Tokyo, Japan.
Citation:
Ultrastructure of oesophageal melanocytosis. 1991, 418 (6):515-22 Virchows Arch A Pathol Anat Histopathol
Journal:
Virchows Archiv. A, Pathological Anatomy and Histopathology
Issue Date:
1991
URI:
http://hdl.handle.net/10541/108806
PubMed ID:
2058085
Type:
Article
Language:
en
ISSN:
0174-7398
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorYamazaki, Ken
dc.contributor.authorOhmori, Ten
dc.contributor.authorKumagai, Yen
dc.contributor.authorMakuuchi, Hen
dc.contributor.authorEyden, Brian Pen
dc.date.accessioned2010-08-02T10:46:57Z-
dc.date.available2010-08-02T10:46:57Z-
dc.date.issued1991-
dc.identifier.citationUltrastructure of oesophageal melanocytosis. 1991, 418 (6):515-22 Virchows Arch A Pathol Anat Histopatholen
dc.identifier.issn0174-7398-
dc.identifier.pmid2058085-
dc.identifier.urihttp://hdl.handle.net/10541/108806-
dc.description.abstractFour examples of an endoscopically detected oesophageal melanotic lesion were examined by light microscopy, light microscope histochemistry and transmission electron microscopy, and were compared with 13 control samples of normal oesophageal epithelium. By light microscopy, pigmented melanocytes lacking atypia and mitoses were observed amongst the keratinocytes in the basal layer of the oesophageal mucosa. Junctional activity was absent. The mechanism of pigmentation was studied and found to consist of: an increase in the number of melanocytes in the basal layer of the mucosa, an increase in the quantity of melanin in these melanocytes, transfer of melanin from melanocytes to keratinocytes and to macrophages and fibroblasts in the tunica propria. Since all the lesions demonstrated increased numbers of both melanocytes and melanosomes, the term oesophageal melanocytosis rather than melanosis is suggested, to emphasise the essential character of the lesion as a cellular proliferation. The value of sampling these pigmented lesions during endoscopy is emphasised as a means of obtaining well-preserved material for the evaluation of a lesion which some authorities have viewed as a possible precursor for oesophageal malignant melanoma.en
dc.language.isoenen
dc.subjectOesophageal Diseasesen
dc.subjectOesophagusen
dc.subject.meshAged-
dc.subject.meshCell Division-
dc.subject.meshEpithelium-
dc.subject.meshEsophageal Diseases-
dc.subject.meshEsophagoscopy-
dc.subject.meshEsophagus-
dc.subject.meshFemale-
dc.subject.meshFibroblasts-
dc.subject.meshHistocytochemistry-
dc.subject.meshHumans-
dc.subject.meshKeratinocytes-
dc.subject.meshMacrophages-
dc.subject.meshMale-
dc.subject.meshMelanins-
dc.subject.meshMelanocytes-
dc.subject.meshMicroscopy, Electron-
dc.subject.meshMiddle Aged-
dc.titleUltrastructure of oesophageal melanocytosis.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, School of Medicine, Keio University, Tokyo, Japan.en
dc.identifier.journalVirchows Archiv. A, Pathological Anatomy and Histopathologyen

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