Male fertility in long-term survivors of childhood acute lymphoblastic leukaemia.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108781
Title:
Male fertility in long-term survivors of childhood acute lymphoblastic leukaemia.
Authors:
Wallace, W Hamish B; Shalet, Stephen M; Lendon, M; Morris-Jones, P H
Abstract:
To study long-term testicular function following the treatment of acute lymphoblastic leukaemia (ALL) in childhood, 37 young adult males were assessed at two separate time points. The initial assessment was made by a wedge testicular biopsy after completion of treatment (median 9.7 years; range 4.1-16.3 years) and the subsequent assessment (median 18.6 years; range 15.4-26.8 years) consisted of the clinical examination of pubertal stage, measurement of serum gonadotrophins and testosterone and, in 19 patients, semen analysis. All 37 men completed pubertal development normally and had a testosterone concentration within the normal adult range. Six men showed evidence of severe damage to the seminiferous epithelium, five were azoospermic and one, who did not provide semen for analysis, had a reduced mean testicular volume (11 mls; normal greater than or equal to 15 mls) and a raised basal FSH level (13 UI 1-1; normal less than or equal to 6 IU 1-1). All six men with germ-cell damage had received either cyclophosphamide or both cyclophosphamide and cytosine arabinoside as part of their chemotherapy regimen. Approximately 10.7 years earlier all 37 men had undergone a testicular biopsy after completion of their chemotherapy. Morphological damage to the seminiferous epithelium had been calculated by estimating the tubular fertility index (TFI), which is the percentage of seminiferous tubules containing identifiable spermatogonia (age-matched normal = 100%).(ABSTRACT TRUNCATED AT 250 WORDS)
Affiliation:
Department of Endocrinology, Christie Hospital, Withington, Manchester, U.K.
Citation:
Male fertility in long-term survivors of childhood acute lymphoblastic leukaemia. 1991, 14 (5):312-9 Int. J. Androl.
Journal:
International Journal of Andrology
Issue Date:
Oct-1991
URI:
http://hdl.handle.net/10541/108781
DOI:
10.1111/j.1365-2605.1991.tb01098.x
PubMed ID:
1794916
Type:
Article
Language:
en
ISSN:
0105-6263
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorWallace, W Hamish Ben
dc.contributor.authorShalet, Stephen Men
dc.contributor.authorLendon, Men
dc.contributor.authorMorris-Jones, P Hen
dc.date.accessioned2010-08-02T10:06:12Z-
dc.date.available2010-08-02T10:06:12Z-
dc.date.issued1991-10-
dc.identifier.citationMale fertility in long-term survivors of childhood acute lymphoblastic leukaemia. 1991, 14 (5):312-9 Int. J. Androl.en
dc.identifier.issn0105-6263-
dc.identifier.pmid1794916-
dc.identifier.doi10.1111/j.1365-2605.1991.tb01098.x-
dc.identifier.urihttp://hdl.handle.net/10541/108781-
dc.description.abstractTo study long-term testicular function following the treatment of acute lymphoblastic leukaemia (ALL) in childhood, 37 young adult males were assessed at two separate time points. The initial assessment was made by a wedge testicular biopsy after completion of treatment (median 9.7 years; range 4.1-16.3 years) and the subsequent assessment (median 18.6 years; range 15.4-26.8 years) consisted of the clinical examination of pubertal stage, measurement of serum gonadotrophins and testosterone and, in 19 patients, semen analysis. All 37 men completed pubertal development normally and had a testosterone concentration within the normal adult range. Six men showed evidence of severe damage to the seminiferous epithelium, five were azoospermic and one, who did not provide semen for analysis, had a reduced mean testicular volume (11 mls; normal greater than or equal to 15 mls) and a raised basal FSH level (13 UI 1-1; normal less than or equal to 6 IU 1-1). All six men with germ-cell damage had received either cyclophosphamide or both cyclophosphamide and cytosine arabinoside as part of their chemotherapy regimen. Approximately 10.7 years earlier all 37 men had undergone a testicular biopsy after completion of their chemotherapy. Morphological damage to the seminiferous epithelium had been calculated by estimating the tubular fertility index (TFI), which is the percentage of seminiferous tubules containing identifiable spermatogonia (age-matched normal = 100%).(ABSTRACT TRUNCATED AT 250 WORDS)en
dc.language.isoenen
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshFollicle Stimulating Hormone-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshInfertility, Male-
dc.subject.meshLuteinizing Hormone-
dc.subject.meshMale-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.subject.meshTestis-
dc.subject.meshTestosterone-
dc.subject.meshTime Factors-
dc.titleMale fertility in long-term survivors of childhood acute lymphoblastic leukaemia.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital, Withington, Manchester, U.K.en
dc.identifier.journalInternational Journal of Andrologyen

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