Prognostic factors in colorectal carcinoma treated by preoperative radiotherapy and immediate surgery.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108778
Title:
Prognostic factors in colorectal carcinoma treated by preoperative radiotherapy and immediate surgery.
Authors:
James, Roger D; Haboubi, Najib; Schofield, Philip F; Mellor, M; Salhab, N
Abstract:
The clinicopathologic staging of colorectal cancer is the subject of recent debate. We studied morphologic variables in a series of tumors resected from 284 patients. Half had been prospectively, randomly allocated to receive a 4-day schedule of preoperative pelvic radiotherapy followed by immediate surgery. There was a significant (P less than 0.01) difference in the distribution of tumors of various histopathologic grades between irradiated (XS) and unirradiated (S) patients and borderline differences in the predictive values of venous spread, tumor grading, and local spread. However, these differences were less marked in 180 tumors examined by one review pathologist. They were thought to be due to misinterpretation of changes induced by radiotherapy. No differences were detected in the distribution of tumors of various sizes and Dukes' stage in the XS and S groups. The review pathologist recorded a borderline (P = 0.049) difference in the distribution of tumors of various CEA staining patterns between the XS and S groups. In a Cox regression model. Dukes' staging remained the most important predictive variable for survival and pelvic recurrence in the XS and S groups. Dukes' staging was apparently unchanged by this schedule of preoperative radiotherapy, but Broders' grading may be unreliable. Any new clinicopathologic staging system for colorectal cancer should record when preoperative radiotherapy is delivered. More studies of radiotherapy effects are required.
Affiliation:
Department of Radiotherapy, Christie Hospital, Withington, Manchester, United Kingdom.
Citation:
Prognostic factors in colorectal carcinoma treated by preoperative radiotherapy and immediate surgery. 1991, 34 (7):546-51 Dis. Colon Rectum
Journal:
Diseases of the Colon and Rectum
Issue Date:
Jul-1991
URI:
http://hdl.handle.net/10541/108778
DOI:
10.1007/BF02049892
PubMed ID:
2055140
Type:
Article
Language:
en
ISSN:
0012-3706
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorJames, Roger Den
dc.contributor.authorHaboubi, Najiben
dc.contributor.authorSchofield, Philip Fen
dc.contributor.authorMellor, Men
dc.contributor.authorSalhab, Nen
dc.date.accessioned2010-08-02T09:35:40Z-
dc.date.available2010-08-02T09:35:40Z-
dc.date.issued1991-07-
dc.identifier.citationPrognostic factors in colorectal carcinoma treated by preoperative radiotherapy and immediate surgery. 1991, 34 (7):546-51 Dis. Colon Rectumen
dc.identifier.issn0012-3706-
dc.identifier.pmid2055140-
dc.identifier.doi10.1007/BF02049892-
dc.identifier.urihttp://hdl.handle.net/10541/108778-
dc.description.abstractThe clinicopathologic staging of colorectal cancer is the subject of recent debate. We studied morphologic variables in a series of tumors resected from 284 patients. Half had been prospectively, randomly allocated to receive a 4-day schedule of preoperative pelvic radiotherapy followed by immediate surgery. There was a significant (P less than 0.01) difference in the distribution of tumors of various histopathologic grades between irradiated (XS) and unirradiated (S) patients and borderline differences in the predictive values of venous spread, tumor grading, and local spread. However, these differences were less marked in 180 tumors examined by one review pathologist. They were thought to be due to misinterpretation of changes induced by radiotherapy. No differences were detected in the distribution of tumors of various sizes and Dukes' stage in the XS and S groups. The review pathologist recorded a borderline (P = 0.049) difference in the distribution of tumors of various CEA staining patterns between the XS and S groups. In a Cox regression model. Dukes' staging remained the most important predictive variable for survival and pelvic recurrence in the XS and S groups. Dukes' staging was apparently unchanged by this schedule of preoperative radiotherapy, but Broders' grading may be unreliable. Any new clinicopathologic staging system for colorectal cancer should record when preoperative radiotherapy is delivered. More studies of radiotherapy effects are required.en
dc.language.isoenen
dc.subjectColorectal Canceren
dc.subjectCancer Invasivenessen
dc.subjectCancer Stagingen
dc.subject.meshAdenocarcinoma-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshCarcinoembryonic Antigen-
dc.subject.meshColorectal Neoplasms-
dc.subject.meshCombined Modality Therapy-
dc.subject.meshHumans-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Invasiveness-
dc.subject.meshNeoplasm Staging-
dc.subject.meshPrognosis-
dc.subject.meshRegression Analysis-
dc.subject.meshSurvival Rate-
dc.titlePrognostic factors in colorectal carcinoma treated by preoperative radiotherapy and immediate surgery.en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiotherapy, Christie Hospital, Withington, Manchester, United Kingdom.en
dc.identifier.journalDiseases of the Colon and Rectumen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.