Lymphocyte function related to survival curves in patients with metastatic melanoma treated by chemoimmunotherapy.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108705
Title:
Lymphocyte function related to survival curves in patients with metastatic melanoma treated by chemoimmunotherapy.
Authors:
Thatcher, Nick; Palmer, Michael K; Swindell, Ric; Crowther, Derek
Abstract:
Thirty-eight patients with metastatic melanoma were evaluated immunologically prior to chemoimmunotherapy. The assays used included recall antigen skin hypersensitivity; lymphocyte count; nonspecific T, non-T, and K cell lymphocytotoxicity; and T and B cell rosette enumeration. Survival curves were computed for each of four ranges of values of a given immunologic test. The higher ranges of positive skin tests, lymphocyte count, cytotoxicity, and T and B subpopulation numbers were consistently associated with the longer survivals. The differences reached statistical significance for non-T cell cytotoxicity and B and T cell peripheral blood counts. Pretreatment immune reactivity, particularly that involvingg non-T cell function, appears related to length of survival.
Affiliation:
The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX.
Citation:
Lymphocyte function related to survival curves in patients with metastatic melanoma treated by chemoimmunotherapy. 1978, 4 (1):59-70 Med. Pediatr. Oncol.
Journal:
Medical and Pediatric Oncology
Issue Date:
1978
URI:
http://hdl.handle.net/10541/108705
PubMed ID:
625264
Type:
Article
Language:
en
ISSN:
0098-1532
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorThatcher, Nicken
dc.contributor.authorPalmer, Michael Ken
dc.contributor.authorSwindell, Ricen
dc.contributor.authorCrowther, Dereken
dc.date.accessioned2010-07-30T13:49:18Z-
dc.date.available2010-07-30T13:49:18Z-
dc.date.issued1978-
dc.identifier.citationLymphocyte function related to survival curves in patients with metastatic melanoma treated by chemoimmunotherapy. 1978, 4 (1):59-70 Med. Pediatr. Oncol.en
dc.identifier.issn0098-1532-
dc.identifier.pmid625264-
dc.identifier.urihttp://hdl.handle.net/10541/108705-
dc.description.abstractThirty-eight patients with metastatic melanoma were evaluated immunologically prior to chemoimmunotherapy. The assays used included recall antigen skin hypersensitivity; lymphocyte count; nonspecific T, non-T, and K cell lymphocytotoxicity; and T and B cell rosette enumeration. Survival curves were computed for each of four ranges of values of a given immunologic test. The higher ranges of positive skin tests, lymphocyte count, cytotoxicity, and T and B subpopulation numbers were consistently associated with the longer survivals. The differences reached statistical significance for non-T cell cytotoxicity and B and T cell peripheral blood counts. Pretreatment immune reactivity, particularly that involvingg non-T cell function, appears related to length of survival.en
dc.language.isoenen
dc.subject.meshAntineoplastic Agents-
dc.subject.meshBCG Vaccine-
dc.subject.meshCytotoxicity, Immunologic-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLeukocyte Count-
dc.subject.meshLymphocytes-
dc.subject.meshMale-
dc.subject.meshMelanoma-
dc.subject.meshRemission, Spontaneous-
dc.subject.meshRosette Formation-
dc.subject.meshSkin Tests-
dc.subject.meshTime Factors-
dc.titleLymphocyte function related to survival curves in patients with metastatic melanoma treated by chemoimmunotherapy.en
dc.typeArticleen
dc.contributor.departmentThe Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX.en
dc.identifier.journalMedical and Pediatric Oncologyen
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