Lack of a relationship between colony-forming efficiency and surviving fraction at 2 Gy.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108457
Title:
Lack of a relationship between colony-forming efficiency and surviving fraction at 2 Gy.
Authors:
West, Catharine M L; Davidson, Susan E; Pool, Claire; James, Roger D; Schofield, Philip F
Abstract:
The relationship between in vitro radiation sensitivity and colony-forming efficiency has been examined for primary human tumors of the cervix, colorectum, and lymph gland. Tumors were cultured using the Courtenay-Mills soft agar clonogenic assay and radiosensitivity was assessed as surviving fraction at 2 Gy. There was no correlation between colony-forming efficiency and surviving fraction at 2 Gy, giving confidence to the use of surviving fraction at 2 Gy as a predictor of clinical outcome.
Affiliation:
Cancer Research Campaign Department of Radiobiology, Paterson Institute for Cancer Research, Manchester, United Kingdom.
Citation:
Lack of a relationship between colony-forming efficiency and surviving fraction at 2 Gy. 1991, 126 (2):260-3 Radiat. Res.
Journal:
Radiation Research
Issue Date:
May-1991
URI:
http://hdl.handle.net/10541/108457
PubMed ID:
2023996
Type:
Article
Language:
en
ISSN:
0033-7587
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorWest, Catharine M Len
dc.contributor.authorDavidson, Susan Een
dc.contributor.authorPool, Claireen
dc.contributor.authorJames, Roger Den
dc.contributor.authorSchofield, Philip Fen
dc.date.accessioned2010-07-27T15:35:45Z-
dc.date.available2010-07-27T15:35:45Z-
dc.date.issued1991-05-
dc.identifier.citationLack of a relationship between colony-forming efficiency and surviving fraction at 2 Gy. 1991, 126 (2):260-3 Radiat. Res.en
dc.identifier.issn0033-7587-
dc.identifier.pmid2023996-
dc.identifier.urihttp://hdl.handle.net/10541/108457-
dc.description.abstractThe relationship between in vitro radiation sensitivity and colony-forming efficiency has been examined for primary human tumors of the cervix, colorectum, and lymph gland. Tumors were cultured using the Courtenay-Mills soft agar clonogenic assay and radiosensitivity was assessed as surviving fraction at 2 Gy. There was no correlation between colony-forming efficiency and surviving fraction at 2 Gy, giving confidence to the use of surviving fraction at 2 Gy as a predictor of clinical outcome.en
dc.language.isoenen
dc.subjectCanceren
dc.subjectColonic Canceren
dc.subjectRectal Canceren
dc.subjectTumour Stem Cell Assayen
dc.subjectUterine Cervical Canceren
dc.subject.meshCell Survival-
dc.subject.meshCesium Radioisotopes-
dc.subject.meshColonic Neoplasms-
dc.subject.meshFemale-
dc.subject.meshGamma Rays-
dc.subject.meshHumans-
dc.subject.meshNeoplasms-
dc.subject.meshRectal Neoplasms-
dc.subject.meshTumor Stem Cell Assay-
dc.subject.meshUterine Cervical Neoplasms-
dc.titleLack of a relationship between colony-forming efficiency and surviving fraction at 2 Gy.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Department of Radiobiology, Paterson Institute for Cancer Research, Manchester, United Kingdom.en
dc.identifier.journalRadiation Researchen
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