Near haploid acute lymphoblastic leukemia: seven new cases and a review of the literature.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108432
Title:
Near haploid acute lymphoblastic leukemia: seven new cases and a review of the literature.
Authors:
Gibbons, B; MacCallum, P; Watts, E; Rohatiner, Ama; Webb, D; Katz, F E; Secker-Walker, L M; Temperley, I J; Harrison, Christine J; Campbell, Richard H A
Abstract:
Seven new cases are described of near haploid acute lymphoblastic leukemia (ALL) and the findings reviewed together with updated complete remission duration and survival data for the 21 cases already published. The patients were four males and three females, with an age range 2-19 years; all had an immunophenotype consistent with common ALL. The poor prognostic outlook for patients with near haploid ALL is confirmed by the median remission duration of 14 months for these patients, which is comparable to that for the previously published cases. The pattern of chromosome loss was marked particularly by the presence of two copies of chromosomes 10, 14, 18, 21 and both sex chromosomes. Populations of hyperdiploid cells with double the near haploid number were observed in six of the patients, one of whom demonstrated further clonal evolution, and it is proposed that some cases classified as hyperdiploid ALL with greater than 50 chromosomes may also have arisen from a near haploid stem line.
Affiliation:
Department of Medical Oncology, St Bartholomew's Hospital, London, UK.
Citation:
Near haploid acute lymphoblastic leukemia: seven new cases and a review of the literature. 1991, 5 (9):738-43 Leukemia
Journal:
Leukemia
Issue Date:
Sep-1991
URI:
http://hdl.handle.net/10541/108432
PubMed ID:
1943226
Type:
Article
Language:
en
ISSN:
0887-6924
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorGibbons, Ben
dc.contributor.authorMacCallum, Pen
dc.contributor.authorWatts, Een
dc.contributor.authorRohatiner, Amaen
dc.contributor.authorWebb, Den
dc.contributor.authorKatz, F Een
dc.contributor.authorSecker-Walker, L Men
dc.contributor.authorTemperley, I Jen
dc.contributor.authorHarrison, Christine Jen
dc.contributor.authorCampbell, Richard H Aen
dc.date.accessioned2010-07-27T13:49:04Z-
dc.date.available2010-07-27T13:49:04Z-
dc.date.issued1991-09-
dc.identifier.citationNear haploid acute lymphoblastic leukemia: seven new cases and a review of the literature. 1991, 5 (9):738-43 Leukemiaen
dc.identifier.issn0887-6924-
dc.identifier.pmid1943226-
dc.identifier.urihttp://hdl.handle.net/10541/108432-
dc.description.abstractSeven new cases are described of near haploid acute lymphoblastic leukemia (ALL) and the findings reviewed together with updated complete remission duration and survival data for the 21 cases already published. The patients were four males and three females, with an age range 2-19 years; all had an immunophenotype consistent with common ALL. The poor prognostic outlook for patients with near haploid ALL is confirmed by the median remission duration of 14 months for these patients, which is comparable to that for the previously published cases. The pattern of chromosome loss was marked particularly by the presence of two copies of chromosomes 10, 14, 18, 21 and both sex chromosomes. Populations of hyperdiploid cells with double the near haploid number were observed in six of the patients, one of whom demonstrated further clonal evolution, and it is proposed that some cases classified as hyperdiploid ALL with greater than 50 chromosomes may also have arisen from a near haploid stem line.en
dc.language.isoenen
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshAdolescent-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshChromosome Aberrations-
dc.subject.meshFemale-
dc.subject.meshHaploidy-
dc.subject.meshHumans-
dc.subject.meshImmunophenotyping-
dc.subject.meshMale-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.titleNear haploid acute lymphoblastic leukemia: seven new cases and a review of the literature.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Oncology, St Bartholomew's Hospital, London, UK.en
dc.identifier.journalLeukemiaen

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