The value of anticarcinoembryonic antigen, human milk factor globulin, and antikeratin antibodies in differentiating mesothelioma from lung carcinoma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108426
Title:
The value of anticarcinoembryonic antigen, human milk factor globulin, and antikeratin antibodies in differentiating mesothelioma from lung carcinoma.
Authors:
Joglekar, V M; Oliver, D; Harris, Martin
Abstract:
Monoclonal anticarcinoembryonic antigen (antiCEA), human milk factor globulin (HMFG2), and antikeratin antibodies were assessed for their value in the differential diagnosis of pleural mesothelioma (53 cases) and carcinoma of the lung (60 cases) in material from necropsies. In 40 of the cases pleural biopsies were also studied in the same manner. AntiCEA was found to be the best discriminating antibody for most types of mesothelioma; HMFG2 was slightly less valuable but a useful additional tool. Antikeratin was the least useful. For both antiCEA and HMFG2 antibodies, however, the proportion of carcinomas staining was smaller than in previous studies and this, combined with the positive staining of some mesotheliomas, reduces the value of the reactions in the individual case. Medical panels adjudicating compensation claims should not use these reactions as the sole criteria in deciding the origin of the tumours in these cases.
Affiliation:
Department of Histopathology, North Lonsdale Hospital, Barrow-in-Furness.
Citation:
The value of anticarcinoembryonic antigen, human milk factor globulin, and antikeratin antibodies in differentiating mesothelioma from lung carcinoma. 1991, 48 (1):34-7 Br J Ind Med
Journal:
British Journal of Industrial Medicine
Issue Date:
Jan-1991
URI:
http://hdl.handle.net/10541/108426
PubMed ID:
1704251
Type:
Article
Language:
en
ISSN:
0007-1072
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorJoglekar, V Men
dc.contributor.authorOliver, Den
dc.contributor.authorHarris, Martinen
dc.date.accessioned2010-07-27T12:59:59Z-
dc.date.available2010-07-27T12:59:59Z-
dc.date.issued1991-01-
dc.identifier.citationThe value of anticarcinoembryonic antigen, human milk factor globulin, and antikeratin antibodies in differentiating mesothelioma from lung carcinoma. 1991, 48 (1):34-7 Br J Ind Meden
dc.identifier.issn0007-1072-
dc.identifier.pmid1704251-
dc.identifier.urihttp://hdl.handle.net/10541/108426-
dc.description.abstractMonoclonal anticarcinoembryonic antigen (antiCEA), human milk factor globulin (HMFG2), and antikeratin antibodies were assessed for their value in the differential diagnosis of pleural mesothelioma (53 cases) and carcinoma of the lung (60 cases) in material from necropsies. In 40 of the cases pleural biopsies were also studied in the same manner. AntiCEA was found to be the best discriminating antibody for most types of mesothelioma; HMFG2 was slightly less valuable but a useful additional tool. Antikeratin was the least useful. For both antiCEA and HMFG2 antibodies, however, the proportion of carcinomas staining was smaller than in previous studies and this, combined with the positive staining of some mesotheliomas, reduces the value of the reactions in the individual case. Medical panels adjudicating compensation claims should not use these reactions as the sole criteria in deciding the origin of the tumours in these cases.en
dc.language.isoenen
dc.subjectCancer Antigensen
dc.subjectLung Canceren
dc.subjectPleural Canceren
dc.subjectBiological Tumour Markersen
dc.subject.meshAntigens, Neoplasm-
dc.subject.meshAutoantibodies-
dc.subject.meshCarcinoembryonic Antigen-
dc.subject.meshCarcinoma-
dc.subject.meshDiagnosis, Differential-
dc.subject.meshHumans-
dc.subject.meshKeratins-
dc.subject.meshLung Neoplasms-
dc.subject.meshMembrane Glycoproteins-
dc.subject.meshMesothelioma-
dc.subject.meshMucin-1-
dc.subject.meshOccupational Diseases-
dc.subject.meshPleural Neoplasms-
dc.subject.meshTumor Markers, Biological-
dc.titleThe value of anticarcinoembryonic antigen, human milk factor globulin, and antikeratin antibodies in differentiating mesothelioma from lung carcinoma.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, North Lonsdale Hospital, Barrow-in-Furness.en
dc.identifier.journalBritish Journal of Industrial Medicineen
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