Comparative intraperitoneal pharmacokinetics of three platinum analogues.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108406
Title:
Comparative intraperitoneal pharmacokinetics of three platinum analogues.
Authors:
Lind, Michael J; Murphy, D J; Sharma, H; Tinker, N; Smith, A; McAuliffe, C A; Crowther, Derek
Abstract:
The pharmakokinetic profiles of intraperitoneally infused platinum analogues were determined in 13 women exhibiting minimal residual disease following surgery and systemic chemotherapy for epithelial ovarian cancer or fallopian tube carcinoma by following the disposition of tracer doses of 195mPt radiolabel. Six patients received iproplatin, four were given cisplatin and three received carboplatin. The present data demonstrate no difference in the disposition of total platinum between these three analogues, but differences in the kinetics of free platinum may exist.
Affiliation:
CRC Department of Medical Oncology, Christie Hospital, Manchester, UK.
Citation:
Comparative intraperitoneal pharmacokinetics of three platinum analogues. 1991, 28 (4):315-7 Cancer Chemother. Pharmacol
Journal:
Cancer Chemotherapy and Pharmacology
Issue Date:
1991
URI:
http://hdl.handle.net/10541/108406
DOI:
10.1007/BF00685543
PubMed ID:
1879050
Type:
Article
Language:
en
ISSN:
0344-5704
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorLind, Michael Jen
dc.contributor.authorMurphy, D Jen
dc.contributor.authorSharma, Hen
dc.contributor.authorTinker, Nen
dc.contributor.authorSmith, Aen
dc.contributor.authorMcAuliffe, C Aen
dc.contributor.authorCrowther, Dereken
dc.date.accessioned2010-07-27T13:17:48Z-
dc.date.available2010-07-27T13:17:48Z-
dc.date.issued1991-
dc.identifier.citationComparative intraperitoneal pharmacokinetics of three platinum analogues. 1991, 28 (4):315-7 Cancer Chemother. Pharmacolen
dc.identifier.issn0344-5704-
dc.identifier.pmid1879050-
dc.identifier.doi10.1007/BF00685543-
dc.identifier.urihttp://hdl.handle.net/10541/108406-
dc.description.abstractThe pharmakokinetic profiles of intraperitoneally infused platinum analogues were determined in 13 women exhibiting minimal residual disease following surgery and systemic chemotherapy for epithelial ovarian cancer or fallopian tube carcinoma by following the disposition of tracer doses of 195mPt radiolabel. Six patients received iproplatin, four were given cisplatin and three received carboplatin. The present data demonstrate no difference in the disposition of total platinum between these three analogues, but differences in the kinetics of free platinum may exist.en
dc.language.isoenen
dc.subjectFallopian Tube Canceren
dc.subjectOvarian Canceren
dc.subject.meshAntineoplastic Agents-
dc.subject.meshCarboplatin-
dc.subject.meshCisplatin-
dc.subject.meshFallopian Tube Neoplasms-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshInfusions, Parenteral-
dc.subject.meshOrganoplatinum Compounds-
dc.subject.meshOvarian Neoplasms-
dc.subject.meshPlatinum-
dc.subject.meshRadioisotopes-
dc.subject.meshTime Factors-
dc.titleComparative intraperitoneal pharmacokinetics of three platinum analogues.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Medical Oncology, Christie Hospital, Manchester, UK.en
dc.identifier.journalCancer Chemotherapy and Pharmacologyen

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