Sensitivity and specificity of immunohistochemical antibodies used to distinguish between benign and malignant pleural disease: a systematic review of published reports.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108154
Title:
Sensitivity and specificity of immunohistochemical antibodies used to distinguish between benign and malignant pleural disease: a systematic review of published reports.
Authors:
King, J; Thatcher, Nick; Pickering, C; Hasleton, Philip S
Abstract:
AIMS: A systematic review of published reports that have evaluated the ability of immunohistochemistry and argyrophil nucleolar organizing region (AgNOR) staining to distinguish between benign and malignant pleural disease. METHODS: Nineteen relevant papers published during the period 1979-2005 were identified. Individual results of immunohistochemistry for five diagnostic antibodies were extracted to calculate diagnostic sensitivity and specificity. results from five of these studies that had evaluated proliferation markers or AgNOR staining techniques were also summarized. RESULTS: Most antibodies demonstrated poor to moderate diagnostic ability. Desmin and epithelial membrane antigen (EMA) were the most useful, with sensitivity and specificity both above 74%. The combination of EMA and AgNOR was reported as having 95% diagnostic sensitivity. A high MCM2 labelling index also differentiated between benign and malignant pleural disease. CONCLUSIONS: Immunohistochemistry is of limited value, but newer diagnostic methods may be useful additions in this area of pathology. The diagnostic importance of histological features seen on plain tissue sections is emphasized as vital for correctly differentiating between benign pleural disease and malignant pleural mesothelioma.
Affiliation:
Department of Cardiothoracic Surgery, Queen Elizabeth Hospital, Birmingham, UK. julietk@talkzi.com
Citation:
Sensitivity and specificity of immunohistochemical antibodies used to distinguish between benign and malignant pleural disease: a systematic review of published reports. 2006, 49 (6):561-8 Histopathology
Journal:
Histopathology
Issue Date:
Dec-2006
URI:
http://hdl.handle.net/10541/108154
DOI:
10.1111/j.1365-2559.2006.02442.x
PubMed ID:
17163840
Type:
Article
Language:
en
ISSN:
0309-0167
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorKing, Jen
dc.contributor.authorThatcher, Nicken
dc.contributor.authorPickering, Cen
dc.contributor.authorHasleton, Philip Sen
dc.date.accessioned2010-07-22T09:25:27Z-
dc.date.available2010-07-22T09:25:27Z-
dc.date.issued2006-12-
dc.identifier.citationSensitivity and specificity of immunohistochemical antibodies used to distinguish between benign and malignant pleural disease: a systematic review of published reports. 2006, 49 (6):561-8 Histopathologyen
dc.identifier.issn0309-0167-
dc.identifier.pmid17163840-
dc.identifier.doi10.1111/j.1365-2559.2006.02442.x-
dc.identifier.urihttp://hdl.handle.net/10541/108154-
dc.description.abstractAIMS: A systematic review of published reports that have evaluated the ability of immunohistochemistry and argyrophil nucleolar organizing region (AgNOR) staining to distinguish between benign and malignant pleural disease. METHODS: Nineteen relevant papers published during the period 1979-2005 were identified. Individual results of immunohistochemistry for five diagnostic antibodies were extracted to calculate diagnostic sensitivity and specificity. results from five of these studies that had evaluated proliferation markers or AgNOR staining techniques were also summarized. RESULTS: Most antibodies demonstrated poor to moderate diagnostic ability. Desmin and epithelial membrane antigen (EMA) were the most useful, with sensitivity and specificity both above 74%. The combination of EMA and AgNOR was reported as having 95% diagnostic sensitivity. A high MCM2 labelling index also differentiated between benign and malignant pleural disease. CONCLUSIONS: Immunohistochemistry is of limited value, but newer diagnostic methods may be useful additions in this area of pathology. The diagnostic importance of histological features seen on plain tissue sections is emphasized as vital for correctly differentiating between benign pleural disease and malignant pleural mesothelioma.en
dc.language.isoenen
dc.subjectCancer Antigensen
dc.subjectPleural Canceren
dc.subjectBiological Tumour Markersen
dc.subject.meshAntigens, Neoplasm-
dc.subject.meshAntigens, Nuclear-
dc.subject.meshDiagnosis, Differential-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshMesothelioma-
dc.subject.meshNuclear Proteins-
dc.subject.meshNucleolus Organizer Region-
dc.subject.meshPleural Neoplasms-
dc.subject.meshPredictive Value of Tests-
dc.subject.meshSensitivity and Specificity-
dc.subject.meshSilver Staining-
dc.subject.meshTumor Markers, Biological-
dc.titleSensitivity and specificity of immunohistochemical antibodies used to distinguish between benign and malignant pleural disease: a systematic review of published reports.en
dc.typeArticleen
dc.contributor.departmentDepartment of Cardiothoracic Surgery, Queen Elizabeth Hospital, Birmingham, UK. julietk@talkzi.comen
dc.identifier.journalHistopathologyen
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