Immunoscintigraphy with 99mTc labelled F(ab')2 fragments of an anti melanoma monoclonal antibody (225.28S) in patients with metastatic malignant melanoma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108116
Title:
Immunoscintigraphy with 99mTc labelled F(ab')2 fragments of an anti melanoma monoclonal antibody (225.28S) in patients with metastatic malignant melanoma.
Authors:
Cerny, T; Owens, Susan E; Mackenzie, S A; Nuttall, Pamela M; Gosh, Anna K; Smith, David B; Thatcher, Nick
Abstract:
Immunoscintigraphy was performed in 25 patients with malignant melanoma using a 99mTc labelled monoclonal antibody (225.28S). In four cases, imaging was repeated following treatment with recombinant gamma interferon. In 11 cases, tissue samples of metastatic lesions were investigated for the expression of melanoma associated antigens by immunohistochemical techniques. Overall, 59% of known lesions were detected by imaging. The highest rates of detection were in bone, liver and lymph nodes and the lowest in lung, stomach and bowel. Six lesions were detected which had not shown up on routine clinical and radiological examination. There was no evidence of enhanced or induced HMW-MAA expression following interferon treatment. This technique has been found to be useful in staging patients and has been free from side effects.
Citation:
Immunoscintigraphy with 99mTc labelled F(ab')2 fragments of an anti melanoma monoclonal antibody (225.28S) in patients with metastatic malignant melanoma. 1987, 13 (3):130-3 Eur J Nucl Med
Journal:
European Journal of Nuclear Medicine
Issue Date:
1987
URI:
http://hdl.handle.net/10541/108116
PubMed ID:
3622556
Type:
Article
Language:
en
ISSN:
0340-6997
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorCerny, Ten
dc.contributor.authorOwens, Susan Een
dc.contributor.authorMackenzie, S Aen
dc.contributor.authorNuttall, Pamela Men
dc.contributor.authorGosh, Anna Ken
dc.contributor.authorSmith, David Ben
dc.contributor.authorThatcher, Nicken
dc.date.accessioned2010-07-21T16:12:24Z-
dc.date.available2010-07-21T16:12:24Z-
dc.date.issued1987-
dc.identifier.citationImmunoscintigraphy with 99mTc labelled F(ab')2 fragments of an anti melanoma monoclonal antibody (225.28S) in patients with metastatic malignant melanoma. 1987, 13 (3):130-3 Eur J Nucl Meden
dc.identifier.issn0340-6997-
dc.identifier.pmid3622556-
dc.identifier.urihttp://hdl.handle.net/10541/108116-
dc.description.abstractImmunoscintigraphy was performed in 25 patients with malignant melanoma using a 99mTc labelled monoclonal antibody (225.28S). In four cases, imaging was repeated following treatment with recombinant gamma interferon. In 11 cases, tissue samples of metastatic lesions were investigated for the expression of melanoma associated antigens by immunohistochemical techniques. Overall, 59% of known lesions were detected by imaging. The highest rates of detection were in bone, liver and lymph nodes and the lowest in lung, stomach and bowel. Six lesions were detected which had not shown up on routine clinical and radiological examination. There was no evidence of enhanced or induced HMW-MAA expression following interferon treatment. This technique has been found to be useful in staging patients and has been free from side effects.en
dc.language.isoenen
dc.subjectCancer Antigensen
dc.subjectCancer Metastasisen
dc.subjectCancer Proteinsen
dc.subjectSkin Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAntibodies, Monoclonal-
dc.subject.meshAntibody Specificity-
dc.subject.meshAntigens, Neoplasm-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHumans-
dc.subject.meshImmunoglobulin Fab Fragments-
dc.subject.meshMale-
dc.subject.meshMelanoma-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Metastasis-
dc.subject.meshNeoplasm Proteins-
dc.subject.meshSkin Neoplasms-
dc.titleImmunoscintigraphy with 99mTc labelled F(ab')2 fragments of an anti melanoma monoclonal antibody (225.28S) in patients with metastatic malignant melanoma.en
dc.typeArticleen
dc.identifier.journalEuropean Journal of Nuclear Medicineen

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