Effects of repeated Corynebacterium parvum and BCG therapy on immune parameters: a weekly sequential study of melanoma patients. I. Changes in non-specific (NK, K and T cell) lymphocytotoxicity, peripheral blood counts and delayed hypersensitivity reactions.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108102
Title:
Effects of repeated Corynebacterium parvum and BCG therapy on immune parameters: a weekly sequential study of melanoma patients. I. Changes in non-specific (NK, K and T cell) lymphocytotoxicity, peripheral blood counts and delayed hypersensitivity reactions.
Authors:
Thatcher, Nick; Swindell, Ric; Crowther, Derek
Abstract:
Increased lymphocyte cytotoxicity, particularly of 'killer' K cell type was recorded with repeated immunizations of either C. parvum or BCG. A 3 week interval between immunizations was capable of maintaining the increase in cytotoxicity. No marked alterations of 'recall' skin hypersensitivity reactions nor of peripheral blood counts were noted. Expression of cytotoxicity results as percentage 51Cr release, lytic units/ml and cytotoxic capacity (after logit transformation of the cytotoxicity-lymphocyte curves) are described. A 3 week immunization schedule is suggested where BCG and C. parvum are used as immunotherapeutic agents, in the doses quoted.
Citation:
Effects of repeated Corynebacterium parvum and BCG therapy on immune parameters: a weekly sequential study of melanoma patients. I. Changes in non-specific (NK, K and T cell) lymphocytotoxicity, peripheral blood counts and delayed hypersensitivity reactions. 1979, 36 (2):227-36 Clin. Exp. Immunol.
Journal:
Clinical and Experimental Immunology
Issue Date:
May-1979
URI:
http://hdl.handle.net/10541/108102
PubMed ID:
314367
Type:
Article
Language:
en
ISSN:
0009-9104
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorThatcher, Nicken
dc.contributor.authorSwindell, Ricen
dc.contributor.authorCrowther, Dereken
dc.date.accessioned2010-07-21T15:21:32Z-
dc.date.available2010-07-21T15:21:32Z-
dc.date.issued1979-05-
dc.identifier.citationEffects of repeated Corynebacterium parvum and BCG therapy on immune parameters: a weekly sequential study of melanoma patients. I. Changes in non-specific (NK, K and T cell) lymphocytotoxicity, peripheral blood counts and delayed hypersensitivity reactions. 1979, 36 (2):227-36 Clin. Exp. Immunol.en
dc.identifier.issn0009-9104-
dc.identifier.pmid314367-
dc.identifier.urihttp://hdl.handle.net/10541/108102-
dc.description.abstractIncreased lymphocyte cytotoxicity, particularly of 'killer' K cell type was recorded with repeated immunizations of either C. parvum or BCG. A 3 week interval between immunizations was capable of maintaining the increase in cytotoxicity. No marked alterations of 'recall' skin hypersensitivity reactions nor of peripheral blood counts were noted. Expression of cytotoxicity results as percentage 51Cr release, lytic units/ml and cytotoxic capacity (after logit transformation of the cytotoxicity-lymphocyte curves) are described. A 3 week immunization schedule is suggested where BCG and C. parvum are used as immunotherapeutic agents, in the doses quoted.en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshBCG Vaccine-
dc.subject.meshBacterial Vaccines-
dc.subject.meshCytotoxicity, Immunologic-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshHypersensitivity, Delayed-
dc.subject.meshImmunization Schedule-
dc.subject.meshKiller Cells, Natural-
dc.subject.meshLeukocyte Count-
dc.subject.meshLymphocytes-
dc.subject.meshMale-
dc.subject.meshMelanoma-
dc.subject.meshMiddle Aged-
dc.subject.meshPropionibacterium acnes-
dc.subject.meshT-Lymphocytes-
dc.titleEffects of repeated Corynebacterium parvum and BCG therapy on immune parameters: a weekly sequential study of melanoma patients. I. Changes in non-specific (NK, K and T cell) lymphocytotoxicity, peripheral blood counts and delayed hypersensitivity reactions.en
dc.typeArticleen
dc.identifier.journalClinical and Experimental Immunologyen
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