Expression of epidermal growth factor receptor (EGF-R) in non-small cell lung cancer. Use of archival tissue and correlation of EGF-R with histology, tumour size, node status and survival.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108096
Title:
Expression of epidermal growth factor receptor (EGF-R) in non-small cell lung cancer. Use of archival tissue and correlation of EGF-R with histology, tumour size, node status and survival.
Authors:
Dazzi, H; Hasleton, Philip S; Thatcher, Nick; Barnes, Diana M; Wilkes, S; Swindell, Ric; Lawson, R A M
Abstract:
A total of 152 non-small cell lung cancers (NSCLC) were studied retrospectively to determine the relationship between epidermal growth factor receptor (EGF-R) status and the histological type, tumour size, nodal status and prognosis. EGF-R status was assessed on routinely embedded paraffin sections with an antibody to the cytoplasmic domain of the tumour (F4 antibody). EGF was demonstrated in all tumour types and every squamous and large cell carcinoma was positive for the antibody. Most tumours showed heterogeneity of staining. EGF expression was seen statistically more frequently in well differentiated tumours. Patients with 50% or more tumour cells showing positivity tended to have an improved survival but this result failed to reach statistical significance. There was no relationship between the size of the primary tumour or the lymph node status. Other cells, such as mucinous glands, bronchial epithelial cells and macrophages stained positively with the monoclonal antibody. EGF receptor status, with the antibodies presently available, adds little to help in either diagnosis or prognosis. Interpretation of data has to be guarded since the antibody was seen in some normal cells.
Affiliation:
Department of Medical Oncology, Christie Hospital, Manchester, UK.
Citation:
Expression of epidermal growth factor receptor (EGF-R) in non-small cell lung cancer. Use of archival tissue and correlation of EGF-R with histology, tumour size, node status and survival. 1989, 59 (5):746-9 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
May-1989
URI:
http://hdl.handle.net/10541/108096
PubMed ID:
2544220
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorDazzi, Hen
dc.contributor.authorHasleton, Philip Sen
dc.contributor.authorThatcher, Nicken
dc.contributor.authorBarnes, Diana Men
dc.contributor.authorWilkes, Sen
dc.contributor.authorSwindell, Ricen
dc.contributor.authorLawson, R A Men
dc.date.accessioned2010-07-21T15:08:47Z-
dc.date.available2010-07-21T15:08:47Z-
dc.date.issued1989-05-
dc.identifier.citationExpression of epidermal growth factor receptor (EGF-R) in non-small cell lung cancer. Use of archival tissue and correlation of EGF-R with histology, tumour size, node status and survival. 1989, 59 (5):746-9 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid2544220-
dc.identifier.urihttp://hdl.handle.net/10541/108096-
dc.description.abstractA total of 152 non-small cell lung cancers (NSCLC) were studied retrospectively to determine the relationship between epidermal growth factor receptor (EGF-R) status and the histological type, tumour size, nodal status and prognosis. EGF-R status was assessed on routinely embedded paraffin sections with an antibody to the cytoplasmic domain of the tumour (F4 antibody). EGF was demonstrated in all tumour types and every squamous and large cell carcinoma was positive for the antibody. Most tumours showed heterogeneity of staining. EGF expression was seen statistically more frequently in well differentiated tumours. Patients with 50% or more tumour cells showing positivity tended to have an improved survival but this result failed to reach statistical significance. There was no relationship between the size of the primary tumour or the lymph node status. Other cells, such as mucinous glands, bronchial epithelial cells and macrophages stained positively with the monoclonal antibody. EGF receptor status, with the antibodies presently available, adds little to help in either diagnosis or prognosis. Interpretation of data has to be guarded since the antibody was seen in some normal cells.en
dc.language.isoenen
dc.subjectLung Canceren
dc.subjectCancer Stagingen
dc.subject.meshCarcinoma, Non-Small-Cell Lung-
dc.subject.meshHumans-
dc.subject.meshLung Neoplasms-
dc.subject.meshLymphatic Metastasis-
dc.subject.meshNeoplasm Staging-
dc.subject.meshReceptor, Epidermal Growth Factor-
dc.titleExpression of epidermal growth factor receptor (EGF-R) in non-small cell lung cancer. Use of archival tissue and correlation of EGF-R with histology, tumour size, node status and survival.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Oncology, Christie Hospital, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren

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