Lymphocyte function in the blood of patients with untreated non-Hodgkin lymphoma: influence of stage and pathology.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108095
Title:
Lymphocyte function in the blood of patients with untreated non-Hodgkin lymphoma: influence of stage and pathology.
Authors:
Thatcher, Nick; Gasiunas, Nijole; Crowther, Derek
Abstract:
Lymphocytotoxicity of T, non-T and K cells was found to be diminished in a proportion of 30 patients with untreated non-Hodgkin lymphoma; T cell number as enumerated by E sheep cell rosettes was also reduced. The reduction was greatest in patients with disease of unfavorable pathology; the effect of stage on these tests was not marked. Decreased skin reactivity was found in the same group of patients with unfavorable pathology. The reduction of direct and antibody dependent lymphocytotoxicity was not related to an obvious reduction in non-T cell numbers, as assessed by rosetting tests. There was, however, a decrease in phytohemagglutinin cytotoxicity in those groups with reduced T cell number. The influence of unfavorable pathology on lymphocyte effector function is emphasized by this study.
Affiliation:
1Cancer Research Campaign Department of Medical Oncology of Manchester University, Christie Hospital and Holt Radium Institute, Withington, Manchester, England.
Citation:
Lymphocyte function in the blood of patients with untreated non-Hodgkin lymphoma: influence of stage and pathology. 1977, 3 (3):311-21 Med. Pediatr. Oncol.
Journal:
Medical and Pediatric Oncology
Issue Date:
1977
URI:
http://hdl.handle.net/10541/108095
DOI:
10.1002/mpo.2950030313
PubMed ID:
311411
Type:
Article
Language:
en
ISSN:
0098-1532
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorThatcher, Nicken
dc.contributor.authorGasiunas, Nijoleen
dc.contributor.authorCrowther, Dereken
dc.date.accessioned2010-07-21T15:06:15Z-
dc.date.available2010-07-21T15:06:15Z-
dc.date.issued1977-
dc.identifier.citationLymphocyte function in the blood of patients with untreated non-Hodgkin lymphoma: influence of stage and pathology. 1977, 3 (3):311-21 Med. Pediatr. Oncol.en
dc.identifier.issn0098-1532-
dc.identifier.pmid311411-
dc.identifier.doi10.1002/mpo.2950030313-
dc.identifier.urihttp://hdl.handle.net/10541/108095-
dc.description.abstractLymphocytotoxicity of T, non-T and K cells was found to be diminished in a proportion of 30 patients with untreated non-Hodgkin lymphoma; T cell number as enumerated by E sheep cell rosettes was also reduced. The reduction was greatest in patients with disease of unfavorable pathology; the effect of stage on these tests was not marked. Decreased skin reactivity was found in the same group of patients with unfavorable pathology. The reduction of direct and antibody dependent lymphocytotoxicity was not related to an obvious reduction in non-T cell numbers, as assessed by rosetting tests. There was, however, a decrease in phytohemagglutinin cytotoxicity in those groups with reduced T cell number. The influence of unfavorable pathology on lymphocyte effector function is emphasized by this study.en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAntibody-Dependent Cell Cytotoxicity-
dc.subject.meshCytotoxicity Tests, Immunologic-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLymphocytes-
dc.subject.meshLymphoma-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshRosette Formation-
dc.subject.meshSkin Tests-
dc.subject.meshT-Lymphocytes-
dc.titleLymphocyte function in the blood of patients with untreated non-Hodgkin lymphoma: influence of stage and pathology.en
dc.typeArticleen
dc.contributor.department1Cancer Research Campaign Department of Medical Oncology of Manchester University, Christie Hospital and Holt Radium Institute, Withington, Manchester, England.en
dc.identifier.journalMedical and Pediatric Oncologyen

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