Effects of BCG and Corynebacterium parvum on immune reactivity in melanoma patients.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108094
Title:
Effects of BCG and Corynebacterium parvum on immune reactivity in melanoma patients.
Authors:
Thatcher, Nick; Crowther, Derek
Abstract:
Sixteen patients with disseminated melanoma were immunised with either BCG (8 cases) or C. parvum (8 cases) on three occasions at 21 day intervals. Blood for assay was taken immediately before the first immunisation and weekly for eight weeks thereafter. Total white count tended to increase but little change was seen in lymphocyte and monocyte counts. Serum IgG increased after BCG BUT NOT WITH C. parvum, serum IgA and IgM did not alter. The 'E' rosette % did show some increase mainly after C. parvum, and 'B' lymphoid cells (sIg staining) increased slightly after BCG; the 'EA' rosette % fell following C. parvum but not after BCG. Lymphocyte PHA blastogenesis increased after immunisation, particularly with BCG. Non-specific lymphocytotoxicity (51 Cr Chang target) demonstrated dramatic increases for 'non T' and 'K' cell function and a smaller increase in 'T' cell cytotoxicity following immunisation. These increases in cytotoxicity were maintained by the 21 day immunisation schedule.
Citation:
Effects of BCG and Corynebacterium parvum on immune reactivity in melanoma patients., 38:449-53 Dev. Biol. Stand.
Journal:
Developments in Biological Standardization
Issue Date:
21-Jul-2010
URI:
http://hdl.handle.net/10541/108094
PubMed ID:
608536
Type:
Article
Language:
en
ISSN:
0301-5149
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorThatcher, Nicken
dc.contributor.authorCrowther, Dereken
dc.date.accessioned2010-07-21T15:05:17Z-
dc.date.available2010-07-21T15:05:17Z-
dc.date.issued2010-07-21T15:05:17Z-
dc.identifier.citationEffects of BCG and Corynebacterium parvum on immune reactivity in melanoma patients., 38:449-53 Dev. Biol. Stand.en
dc.identifier.issn0301-5149-
dc.identifier.pmid608536-
dc.identifier.urihttp://hdl.handle.net/10541/108094-
dc.description.abstractSixteen patients with disseminated melanoma were immunised with either BCG (8 cases) or C. parvum (8 cases) on three occasions at 21 day intervals. Blood for assay was taken immediately before the first immunisation and weekly for eight weeks thereafter. Total white count tended to increase but little change was seen in lymphocyte and monocyte counts. Serum IgG increased after BCG BUT NOT WITH C. parvum, serum IgA and IgM did not alter. The 'E' rosette % did show some increase mainly after C. parvum, and 'B' lymphoid cells (sIg staining) increased slightly after BCG; the 'EA' rosette % fell following C. parvum but not after BCG. Lymphocyte PHA blastogenesis increased after immunisation, particularly with BCG. Non-specific lymphocytotoxicity (51 Cr Chang target) demonstrated dramatic increases for 'non T' and 'K' cell function and a smaller increase in 'T' cell cytotoxicity following immunisation. These increases in cytotoxicity were maintained by the 21 day immunisation schedule.en
dc.language.isoenen
dc.subjectSkin Canceren
dc.subject.meshBCG Vaccine-
dc.subject.meshCytotoxicity Tests, Immunologic-
dc.subject.meshHumans-
dc.subject.meshImmunoglobulins-
dc.subject.meshImmunotherapy-
dc.subject.meshLymphocyte Activation-
dc.subject.meshMelanoma-
dc.subject.meshPropionibacterium acnes-
dc.subject.meshRosette Formation-
dc.subject.meshSkin Neoplasms-
dc.titleEffects of BCG and Corynebacterium parvum on immune reactivity in melanoma patients.en
dc.typeArticleen
dc.identifier.journalDevelopments in Biological Standardizationen
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