Effects of repeated Corynebacterium parvum and BCG therapy on immune parameters: a weekly study of melanoma patients II. Changes in serum immunoglobulins and lymphoid cell subpopulations.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108088
Title:
Effects of repeated Corynebacterium parvum and BCG therapy on immune parameters: a weekly study of melanoma patients II. Changes in serum immunoglobulins and lymphoid cell subpopulations.
Authors:
Thatcher, Nick; Swindell, Ric; Crowther, Derek
Abstract:
Two groups, each of eight patients, with metastatic melanoma were immunized with either C. parvum or BCG at 3-weekly intervals. The serum IgG, IgA, IgM levels, E-rosettes, EA-rosetts, sIg-bearing cells, 'null cells' and lymphocyte blastogenesis at four PHA concentrations were assayed, before immunization and weekly thereafter for 8 weeks. The pre-immunization E-rosette values were significantly reduced, with a significant increase in 'null cell' values and EA-rosette percentages, when compared with healthy controls. Following C. parvum immunization, significant increases occurred in E-rosette percentages with decreases in EA-rosette and 'null cell' counts. A significant reduction in 'null cell' values also occurred with BCG. Other parameters including PHA blastogenesis did not exhibit statistically significant changes. Different methods of expressing the results (particularly of blastogenesis data) were compared, as were the similarities between the present investigation and a study of the effects of a single immunization. The relationship between the subpopulation changes and lymphocyte cytotoxicity described in an earlier article (Thatcher, Swindell & Crowther, 1979a) is discussed.
Affiliation:
Cancer Research Campaign, Department of Medical Oncology of Manchester University.
Citation:
Effects of repeated Corynebacterium parvum and BCG therapy on immune parameters: a weekly study of melanoma patients II. Changes in serum immunoglobulins and lymphoid cell subpopulations. 1979, 36 (3):456-64 Clin. Exp. Immunol.
Journal:
Clinical and Experimental Immunology
Issue Date:
Jun-1979
URI:
http://hdl.handle.net/10541/108088
PubMed ID:
487647
Type:
Article
Language:
en
ISSN:
0009-9104
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorThatcher, Nicken
dc.contributor.authorSwindell, Ricen
dc.contributor.authorCrowther, Dereken
dc.date.accessioned2010-07-21T14:46:16Z-
dc.date.available2010-07-21T14:46:16Z-
dc.date.issued1979-06-
dc.identifier.citationEffects of repeated Corynebacterium parvum and BCG therapy on immune parameters: a weekly study of melanoma patients II. Changes in serum immunoglobulins and lymphoid cell subpopulations. 1979, 36 (3):456-64 Clin. Exp. Immunol.en
dc.identifier.issn0009-9104-
dc.identifier.pmid487647-
dc.identifier.urihttp://hdl.handle.net/10541/108088-
dc.description.abstractTwo groups, each of eight patients, with metastatic melanoma were immunized with either C. parvum or BCG at 3-weekly intervals. The serum IgG, IgA, IgM levels, E-rosettes, EA-rosetts, sIg-bearing cells, 'null cells' and lymphocyte blastogenesis at four PHA concentrations were assayed, before immunization and weekly thereafter for 8 weeks. The pre-immunization E-rosette values were significantly reduced, with a significant increase in 'null cell' values and EA-rosette percentages, when compared with healthy controls. Following C. parvum immunization, significant increases occurred in E-rosette percentages with decreases in EA-rosette and 'null cell' counts. A significant reduction in 'null cell' values also occurred with BCG. Other parameters including PHA blastogenesis did not exhibit statistically significant changes. Different methods of expressing the results (particularly of blastogenesis data) were compared, as were the similarities between the present investigation and a study of the effects of a single immunization. The relationship between the subpopulation changes and lymphocyte cytotoxicity described in an earlier article (Thatcher, Swindell & Crowther, 1979a) is discussed.en
dc.language.isoenen
dc.subject.meshBCG Vaccine-
dc.subject.meshBacterial Vaccines-
dc.subject.meshHumans-
dc.subject.meshImmunization-
dc.subject.meshImmunoglobulins-
dc.subject.meshLeukocyte Count-
dc.subject.meshLymphocyte Activation-
dc.subject.meshLymphocytes-
dc.subject.meshMelanoma-
dc.subject.meshPropionibacterium acnes-
dc.subject.meshRosette Formation-
dc.subject.meshTime Factors-
dc.titleEffects of repeated Corynebacterium parvum and BCG therapy on immune parameters: a weekly study of melanoma patients II. Changes in serum immunoglobulins and lymphoid cell subpopulations.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign, Department of Medical Oncology of Manchester University.en
dc.identifier.journalClinical and Experimental Immunologyen
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