Effects of Corynebacterium parvum and BCG therapy on immune parameters in patients with disseminated melanoma. A sequential study over 28 days. II. Changes in non-specific (NK, K and T cell) lymphocytoxicity and delayed hypersensitivity skin reactions.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108086
Title:
Effects of Corynebacterium parvum and BCG therapy on immune parameters in patients with disseminated melanoma. A sequential study over 28 days. II. Changes in non-specific (NK, K and T cell) lymphocytoxicity and delayed hypersensitivity skin reactions.
Authors:
Thatcher, Nick; Swindell, Ric; Crowther, Derek
Abstract:
C. parvum and BCG produced significant changes in NK, K and T cell lymphocytotoxicity using a Chang liver target cell. A consistent temporal pattern over 28 days of early depression, recovery, overshoot and then decline was described. This was particularly marked for C. parvum and 'K' cell activity. Skin test reactivity to recall antigens at 28 days was not appreciably different from the pre-immunization reactivity. The importance of using lymphocyte concentration-cytotoxicity titration curves and the linearization of such curves is discussed. An immunotherapy schedule with 3 weekly immunization intervals is proposed as the optimum schedule in patients receiving C. parvum at a dose of 2.0 mg/m2 i.v.
Affiliation:
Cancer Research Campaign Department of Medical Oncology of Manchester University.
Citation:
Effects of Corynebacterium parvum and BCG therapy on immune parameters in patients with disseminated melanoma. A sequential study over 28 days. II. Changes in non-specific (NK, K and T cell) lymphocytoxicity and delayed hypersensitivity skin reactions. 1979, 35 (2):171-9 Clin. Exp. Immunol.
Journal:
Clinical and Experimental Immunology
Issue Date:
Feb-1979
URI:
http://hdl.handle.net/10541/108086
PubMed ID:
312169
Type:
Article
Language:
en
ISSN:
0009-9104
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorThatcher, Nicken
dc.contributor.authorSwindell, Ricen
dc.contributor.authorCrowther, Dereken
dc.date.accessioned2010-07-21T14:29:22Z-
dc.date.available2010-07-21T14:29:22Z-
dc.date.issued1979-02-
dc.identifier.citationEffects of Corynebacterium parvum and BCG therapy on immune parameters in patients with disseminated melanoma. A sequential study over 28 days. II. Changes in non-specific (NK, K and T cell) lymphocytoxicity and delayed hypersensitivity skin reactions. 1979, 35 (2):171-9 Clin. Exp. Immunol.en
dc.identifier.issn0009-9104-
dc.identifier.pmid312169-
dc.identifier.urihttp://hdl.handle.net/10541/108086-
dc.description.abstractC. parvum and BCG produced significant changes in NK, K and T cell lymphocytotoxicity using a Chang liver target cell. A consistent temporal pattern over 28 days of early depression, recovery, overshoot and then decline was described. This was particularly marked for C. parvum and 'K' cell activity. Skin test reactivity to recall antigens at 28 days was not appreciably different from the pre-immunization reactivity. The importance of using lymphocyte concentration-cytotoxicity titration curves and the linearization of such curves is discussed. An immunotherapy schedule with 3 weekly immunization intervals is proposed as the optimum schedule in patients receiving C. parvum at a dose of 2.0 mg/m2 i.v.en
dc.language.isoenen
dc.subject.meshAntibody-Dependent Cell Cytotoxicity-
dc.subject.meshBCG Vaccine-
dc.subject.meshBacterial Vaccines-
dc.subject.meshCytotoxicity, Immunologic-
dc.subject.meshHumans-
dc.subject.meshKiller Cells, Natural-
dc.subject.meshLymphocytes-
dc.subject.meshMelanoma-
dc.subject.meshPropionibacterium acnes-
dc.subject.meshSkin Tests-
dc.subject.meshT-Lymphocytes-
dc.titleEffects of Corynebacterium parvum and BCG therapy on immune parameters in patients with disseminated melanoma. A sequential study over 28 days. II. Changes in non-specific (NK, K and T cell) lymphocytoxicity and delayed hypersensitivity skin reactions.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Department of Medical Oncology of Manchester University.en
dc.identifier.journalClinical and Experimental Immunologyen
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