Human lymphocyte traffic assessed by indium-111 oxine labelling: clinical observations.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108084
Title:
Human lymphocyte traffic assessed by indium-111 oxine labelling: clinical observations.
Authors:
Wagstaff, John; Gibson, C; Thatcher, Nick; Ford, W L; Sharma, H; Crowther, Derek
Abstract:
Clinical studies using indium-111 oxine labelling of human peripheral blood lymphocytes are presented. Data from animal models of lymphocyte migration are compared with results found in healthy subjects and patients with malignant neoplasms. The physiological significance of bone marrow and liver localization on gamma camera imaging is discussed and the importance of considering the surface marker characteristics of the lymphocytes under study, when interpreting results, is emphasized. The possibility that the redistribution of lymphocytes within the body is a cause of the peripheral blood lymphopenia in patients with Hodgkin's disease and other malignancies is suggested, and the usefulness of indium-111 oxine labelling in clarifying this problem is proposed.
Citation:
Human lymphocyte traffic assessed by indium-111 oxine labelling: clinical observations. 1981, 43 (3):443-9 Clin. Exp. Immunol.
Journal:
Clinical and Experimental Immunology
Issue Date:
Mar-1981
URI:
http://hdl.handle.net/10541/108084
PubMed ID:
7285388
Type:
Article
Language:
en
ISSN:
0009-9104
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorWagstaff, Johnen
dc.contributor.authorGibson, Cen
dc.contributor.authorThatcher, Nicken
dc.contributor.authorFord, W Len
dc.contributor.authorSharma, Hen
dc.contributor.authorCrowther, Dereken
dc.date.accessioned2010-07-21T14:20:27Z-
dc.date.available2010-07-21T14:20:27Z-
dc.date.issued1981-03-
dc.identifier.citationHuman lymphocyte traffic assessed by indium-111 oxine labelling: clinical observations. 1981, 43 (3):443-9 Clin. Exp. Immunol.en
dc.identifier.issn0009-9104-
dc.identifier.pmid7285388-
dc.identifier.urihttp://hdl.handle.net/10541/108084-
dc.description.abstractClinical studies using indium-111 oxine labelling of human peripheral blood lymphocytes are presented. Data from animal models of lymphocyte migration are compared with results found in healthy subjects and patients with malignant neoplasms. The physiological significance of bone marrow and liver localization on gamma camera imaging is discussed and the importance of considering the surface marker characteristics of the lymphocytes under study, when interpreting results, is emphasized. The possibility that the redistribution of lymphocytes within the body is a cause of the peripheral blood lymphopenia in patients with Hodgkin's disease and other malignancies is suggested, and the usefulness of indium-111 oxine labelling in clarifying this problem is proposed.en
dc.language.isoenen
dc.subjectCanceren
dc.subject.meshCell Movement-
dc.subject.meshGamma Rays-
dc.subject.meshHumans-
dc.subject.meshIndium-
dc.subject.meshLymphocytes-
dc.subject.meshMale-
dc.subject.meshNeoplasms-
dc.subject.meshRadioisotopes-
dc.titleHuman lymphocyte traffic assessed by indium-111 oxine labelling: clinical observations.en
dc.typeArticleen
dc.identifier.journalClinical and Experimental Immunologyen

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