A comparison between a single agent short course chemotherapy regimen and a quadruple prolonged course regimen for small-cell bronchogenic carcinoma of limited extent.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108073
Title:
A comparison between a single agent short course chemotherapy regimen and a quadruple prolonged course regimen for small-cell bronchogenic carcinoma of limited extent.
Authors:
Carroll, K B; Moussalli, H; Brown, D; Thatcher, Nick
Abstract:
Sixty-eight patients with inoperable but 'limited' stage small-cell carcinoma of the bronchus were treated with two different chemotherapy regimens. Thirty-four patients received methotrexate, cyclophosphamide, procarbazine and vincristine in standard dose over a 2-year schedule. Thirty-four patients received cyclophosphamide alone over a period of 3 months. The groups were evenly balanced with respect to clinical details which are fully described. Toxicity was acceptable. The median actual survival for the whole group was 11 months, the 1-year, 2-year and 4-year survival being 48%, 30% and 1.5% respectively. There was no statistically significant difference in survival between those classified as responders and those as non-responders, nor between the groups treated with the two different regimens. There was a high local recurrence rate.
Affiliation:
Regional Cardiothoracic Unit, Wythenshawe Hospital, Southmoore Road, Manchester 23 UK.
Citation:
A comparison between a single agent short course chemotherapy regimen and a quadruple prolonged course regimen for small-cell bronchogenic carcinoma of limited extent. 1983, 77 (2):171-8 Br J Dis Chest
Journal:
British Journal of Diseases of the Chest
Issue Date:
Apr-1983
URI:
http://hdl.handle.net/10541/108073
DOI:
10.1016/0007-0971(83)90024-4
PubMed ID:
6307334
Type:
Article
Language:
en
ISSN:
0007-0971
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorCarroll, K Ben
dc.contributor.authorMoussalli, Hen
dc.contributor.authorBrown, Den
dc.contributor.authorThatcher, Nicken
dc.date.accessioned2010-07-21T12:27:08Z-
dc.date.available2010-07-21T12:27:08Z-
dc.date.issued1983-04-
dc.identifier.citationA comparison between a single agent short course chemotherapy regimen and a quadruple prolonged course regimen for small-cell bronchogenic carcinoma of limited extent. 1983, 77 (2):171-8 Br J Dis Chesten
dc.identifier.issn0007-0971-
dc.identifier.pmid6307334-
dc.identifier.doi10.1016/0007-0971(83)90024-4-
dc.identifier.urihttp://hdl.handle.net/10541/108073-
dc.description.abstractSixty-eight patients with inoperable but 'limited' stage small-cell carcinoma of the bronchus were treated with two different chemotherapy regimens. Thirty-four patients received methotrexate, cyclophosphamide, procarbazine and vincristine in standard dose over a 2-year schedule. Thirty-four patients received cyclophosphamide alone over a period of 3 months. The groups were evenly balanced with respect to clinical details which are fully described. Toxicity was acceptable. The median actual survival for the whole group was 11 months, the 1-year, 2-year and 4-year survival being 48%, 30% and 1.5% respectively. There was no statistically significant difference in survival between those classified as responders and those as non-responders, nor between the groups treated with the two different regimens. There was a high local recurrence rate.en
dc.language.isoenen
dc.subjectLung Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshCarcinoma, Bronchogenic-
dc.subject.meshCarcinoma, Small Cell-
dc.subject.meshCyclophosphamide-
dc.subject.meshDrug Therapy, Combination-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLung Neoplasms-
dc.subject.meshMale-
dc.subject.meshMethotrexate-
dc.subject.meshMiddle Aged-
dc.subject.meshProcarbazine-
dc.subject.meshVincristine-
dc.titleA comparison between a single agent short course chemotherapy regimen and a quadruple prolonged course regimen for small-cell bronchogenic carcinoma of limited extent.en
dc.typeArticleen
dc.contributor.departmentRegional Cardiothoracic Unit, Wythenshawe Hospital, Southmoore Road, Manchester 23 UK.en
dc.identifier.journalBritish Journal of Diseases of the Chesten
All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.