Effects of Corynebacterium parvum and BCG therapy on immune parameters in patients with disseminated melanoma a sequential study over 28 days. I. Changes in blood counts, serum immunoglobulins and lymphoid cell populations.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108071
Title:
Effects of Corynebacterium parvum and BCG therapy on immune parameters in patients with disseminated melanoma a sequential study over 28 days. I. Changes in blood counts, serum immunoglobulins and lymphoid cell populations.
Authors:
Thatcher, Nick; Swindell, Ric; Crowther, Derek
Abstract:
The effects of a single immunization of melanoma patients with BCG or C. parvum on the blood counts, serum immunoglobulin levels and lymphoid subpopulations were followed by multiple assays over 28 days. C. parvum produced a decrease in the white cell count, lymphocyte count and lymphoid T and sIg+ cell numbers, which recovered within 1 week; BCG did not produce such a marked depression. Both agents were associated with increases in T cell numbers and lymphocyte PHA blastogenesis after the first week; these declined to pre-immunization values by 3-4 weeks. The sIg-bearing cell subpopulation also increased after BCG. Different methods of expression the results were compared and the difficulties of immunological monitoring are discussed.
Affiliation:
Cancer Research Campaign, Department of Medical Oncology, University of Manchester.
Citation:
Effects of Corynebacterium parvum and BCG therapy on immune parameters in patients with disseminated melanoma a sequential study over 28 days. I. Changes in blood counts, serum immunoglobulins and lymphoid cell populations. 1979, 35 (1):36-44 Clin. Exp. Immunol.
Journal:
Clinical and Experimental Immunology
Issue Date:
Jan-1979
URI:
http://hdl.handle.net/10541/108071
PubMed ID:
428146
Type:
Article
Language:
en
ISSN:
0009-9104
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorThatcher, Nicken
dc.contributor.authorSwindell, Ricen
dc.contributor.authorCrowther, Dereken
dc.date.accessioned2010-07-21T14:52:27Z-
dc.date.available2010-07-21T14:52:27Z-
dc.date.issued1979-01-
dc.identifier.citationEffects of Corynebacterium parvum and BCG therapy on immune parameters in patients with disseminated melanoma a sequential study over 28 days. I. Changes in blood counts, serum immunoglobulins and lymphoid cell populations. 1979, 35 (1):36-44 Clin. Exp. Immunol.en
dc.identifier.issn0009-9104-
dc.identifier.pmid428146-
dc.identifier.urihttp://hdl.handle.net/10541/108071-
dc.description.abstractThe effects of a single immunization of melanoma patients with BCG or C. parvum on the blood counts, serum immunoglobulin levels and lymphoid subpopulations were followed by multiple assays over 28 days. C. parvum produced a decrease in the white cell count, lymphocyte count and lymphoid T and sIg+ cell numbers, which recovered within 1 week; BCG did not produce such a marked depression. Both agents were associated with increases in T cell numbers and lymphocyte PHA blastogenesis after the first week; these declined to pre-immunization values by 3-4 weeks. The sIg-bearing cell subpopulation also increased after BCG. Different methods of expression the results were compared and the difficulties of immunological monitoring are discussed.en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshBCG Vaccine-
dc.subject.meshBacterial Vaccines-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunoglobulins-
dc.subject.meshLeukocyte Count-
dc.subject.meshLymphocyte Activation-
dc.subject.meshMale-
dc.subject.meshMelanoma-
dc.subject.meshMiddle Aged-
dc.subject.meshPhytohemagglutinins-
dc.subject.meshPropionibacterium acnes-
dc.subject.meshReceptors, Antigen, B-Cell-
dc.subject.meshRosette Formation-
dc.titleEffects of Corynebacterium parvum and BCG therapy on immune parameters in patients with disseminated melanoma a sequential study over 28 days. I. Changes in blood counts, serum immunoglobulins and lymphoid cell populations.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign, Department of Medical Oncology, University of Manchester.en
dc.identifier.journalClinical and Experimental Immunologyen
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