Expression of epidermal growth factor receptor (EGF-R) in human lung tumours.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108028
Title:
Expression of epidermal growth factor receptor (EGF-R) in human lung tumours.
Authors:
Cerny, T; Barnes, Diana M; Hasleton, Philip S; Barber, Philip V; Healy, K; Gullick, W; Thatcher, Nick
Abstract:
Epidermal growth factor receptor (EGF-R) expression was assessed in 63 lung tumour samples with a monoclonal antibody (EGF-R1) by indirect immunoperoxidase staining on cryostat sections. All 15 small cell lung cancer samples were negative whereas over 80% of the 48 non small lung cancer stained positively. In 30 bronchial biopsies two monoclonal antibodies against the cytoplasmic part of the EGF-R were evaluated. These antibodies showed weaker staining than EGF-R1. No additional or enhanced staining as compared with EGF-R1 was observed, suggesting a lack of enhanced expression of a truncated EGF-R analogous to the v-erb-B oncogene product. Monoclonal antibodies against the EGF-R may be helpful diagnostically in differentiating small cell from non small cell lung cancer and may also be important in elucidating biological differences in primary lung cancer.
Affiliation:
Department of Medical Oncology, Christie Hospital, Manchester, UK.
Citation:
Expression of epidermal growth factor receptor (EGF-R) in human lung tumours. 1986, 54 (2):265-9 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
Aug-1986
URI:
http://hdl.handle.net/10541/108028
PubMed ID:
3017396
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorCerny, Ten
dc.contributor.authorBarnes, Diana Men
dc.contributor.authorHasleton, Philip Sen
dc.contributor.authorBarber, Philip Ven
dc.contributor.authorHealy, Ken
dc.contributor.authorGullick, Wen
dc.contributor.authorThatcher, Nicken
dc.date.accessioned2010-07-21T10:11:22Z-
dc.date.available2010-07-21T10:11:22Z-
dc.date.issued1986-08-
dc.identifier.citationExpression of epidermal growth factor receptor (EGF-R) in human lung tumours. 1986, 54 (2):265-9 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid3017396-
dc.identifier.urihttp://hdl.handle.net/10541/108028-
dc.description.abstractEpidermal growth factor receptor (EGF-R) expression was assessed in 63 lung tumour samples with a monoclonal antibody (EGF-R1) by indirect immunoperoxidase staining on cryostat sections. All 15 small cell lung cancer samples were negative whereas over 80% of the 48 non small lung cancer stained positively. In 30 bronchial biopsies two monoclonal antibodies against the cytoplasmic part of the EGF-R were evaluated. These antibodies showed weaker staining than EGF-R1. No additional or enhanced staining as compared with EGF-R1 was observed, suggesting a lack of enhanced expression of a truncated EGF-R analogous to the v-erb-B oncogene product. Monoclonal antibodies against the EGF-R may be helpful diagnostically in differentiating small cell from non small cell lung cancer and may also be important in elucidating biological differences in primary lung cancer.en
dc.language.isoenen
dc.subject.meshAdenocarcinoma-
dc.subject.meshAntibodies, Monoclonal-
dc.subject.meshCarcinoma, Small Cell-
dc.subject.meshCarcinoma, Squamous Cell-
dc.subject.meshEpidermal Growth Factor-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunoenzyme Techniques-
dc.subject.meshLung Neoplasms-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshReceptor, Epidermal Growth Factor-
dc.subject.meshReceptors, Cell Surface-
dc.titleExpression of epidermal growth factor receptor (EGF-R) in human lung tumours.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Oncology, Christie Hospital, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren

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