Prevalence of the Rhesus-negative phenotype in Caucasian patients with small-cell lung cancer (SCLC).

2.50
Hdl Handle:
http://hdl.handle.net/10541/108025
Title:
Prevalence of the Rhesus-negative phenotype in Caucasian patients with small-cell lung cancer (SCLC).
Authors:
Cerny, T; Fey, M F; Oppliger, R; Castiglione, M; Nachbur, B; Gertsch, M; Gasser, A; Joss, R A; Thatcher, Nick; Lind, Michael J; Von Rohr, A
Abstract:
We report that the Rhesus (Rh)-negative phenotype is more prevalent in patients with small-cell lung cancer (SCLC) than in the normal Caucasian population (SCLC: 25% Rh-negative vs. 15% expected, p less than 0.0001). This finding has been validated for a Central and a Northern European population (Switzerland and UK). In contrast, the Rh-negative phenotype is no more frequent in non-small-cell lung cancer patients or in heavy smokers with coronary heart disease than in the general population. There was a normal distribution of the ABO blood group phenotype in all patients studied. Whilst the significance of this observation is unclear, we hypothesize that a genetic predisposition to the development of SCLC may be linked to a hitherto unidentified gene on chromosome 1p near the Rh locus. Our observation may perhaps allow further progress to be made in understanding genetic mechanisms of SCLC carcinogenesis.
Affiliation:
Institute of Medical Oncology, Inselspital, Berne, Switzerland.
Citation:
Prevalence of the Rhesus-negative phenotype in Caucasian patients with small-cell lung cancer (SCLC). 1992, 52 (3):504-6 Int J Cancer
Journal:
International Journal of Cancer
Issue Date:
30-Sep-1992
URI:
http://hdl.handle.net/10541/108025
PubMed ID:
1328070
Type:
Article
Language:
en
ISSN:
0020-7136
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorCerny, Ten
dc.contributor.authorFey, M Fen
dc.contributor.authorOppliger, Ren
dc.contributor.authorCastiglione, Men
dc.contributor.authorNachbur, Ben
dc.contributor.authorGertsch, Men
dc.contributor.authorGasser, Aen
dc.contributor.authorJoss, R Aen
dc.contributor.authorThatcher, Nicken
dc.contributor.authorLind, Michael Jen
dc.contributor.authorVon Rohr, Aen
dc.date.accessioned2010-07-21T09:27:32Z-
dc.date.available2010-07-21T09:27:32Z-
dc.date.issued1992-09-30-
dc.identifier.citationPrevalence of the Rhesus-negative phenotype in Caucasian patients with small-cell lung cancer (SCLC). 1992, 52 (3):504-6 Int J Canceren
dc.identifier.issn0020-7136-
dc.identifier.pmid1328070-
dc.identifier.urihttp://hdl.handle.net/10541/108025-
dc.description.abstractWe report that the Rhesus (Rh)-negative phenotype is more prevalent in patients with small-cell lung cancer (SCLC) than in the normal Caucasian population (SCLC: 25% Rh-negative vs. 15% expected, p less than 0.0001). This finding has been validated for a Central and a Northern European population (Switzerland and UK). In contrast, the Rh-negative phenotype is no more frequent in non-small-cell lung cancer patients or in heavy smokers with coronary heart disease than in the general population. There was a normal distribution of the ABO blood group phenotype in all patients studied. Whilst the significance of this observation is unclear, we hypothesize that a genetic predisposition to the development of SCLC may be linked to a hitherto unidentified gene on chromosome 1p near the Rh locus. Our observation may perhaps allow further progress to be made in understanding genetic mechanisms of SCLC carcinogenesis.en
dc.language.isoenen
dc.subjectLung Canceren
dc.subject.meshABO Blood-Group System-
dc.subject.meshCarcinoma, Small Cell-
dc.subject.meshEuropean Continental Ancestry Group-
dc.subject.meshHumans-
dc.subject.meshLung Neoplasms-
dc.subject.meshPhenotype-
dc.subject.meshPrevalence-
dc.subject.meshRh-Hr Blood-Group System-
dc.titlePrevalence of the Rhesus-negative phenotype in Caucasian patients with small-cell lung cancer (SCLC).en
dc.typeArticleen
dc.contributor.departmentInstitute of Medical Oncology, Inselspital, Berne, Switzerland.en
dc.identifier.journalInternational Journal of Canceren

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