Pretreatment prognostic factors and scoring system in 407 small-cell lung cancer patients.

2.50
Hdl Handle:
http://hdl.handle.net/10541/108003
Title:
Pretreatment prognostic factors and scoring system in 407 small-cell lung cancer patients.
Authors:
Cerny, T; Blair, Val; Anderson, Heather; Bramwell, Vivien H C; Thatcher, Nick
Abstract:
In 407 patients with small-cell lung cancer (SCLC), 61 pretreatment variables were evaluated in a Cox multiple regression analysis to assess their prognostic value. All patients received short-term intensive regimens (cyclophosphamide, etoposide and methotrexate or ifosfamide and etoposide, both followed by thoracic irradiation if complete response was noted). Lactate dehydrogenase (p = 0.001), tumour stage (p = 0.0001), serum sodium (p = 0.0009), pretreatment Karnofsky performance score (p = 0.0121), alkaline phosphatase (p = 0.0186) and serum bicarbonate (p = 0.0321) were the important prognostic factors. Once these variables were taken into account no other variable provided additional prognostic information. A simple scoring system ("Manchester Score") using these variables was established and shows little loss of information compared to the Cox analysis. The score distinguishes 3 prognostic groups, the best of which contains all long-term survivors, whereas the bad prognostic group contains no patient surviving longer than one year. The scoring system may help to design new treatment strategies and may also facilitate the comparison of different studies.
Affiliation:
Institut fuer Medizinische Onkologie, Universitaet Bern, Inselspital, CH-3010 Bern, Switzerland
Citation:
Pretreatment prognostic factors and scoring system in 407 small-cell lung cancer patients. 1987, 39 (2):146-9 Int. J. Cancer
Journal:
International Journal of Cancer
Issue Date:
15-Feb-1987
URI:
http://hdl.handle.net/10541/108003
DOI:
10.1002/ijc.2910390204
PubMed ID:
3026969
Type:
Article
Language:
en
ISSN:
0020-7136
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorCerny, Ten
dc.contributor.authorBlair, Valen
dc.contributor.authorAnderson, Heatheren
dc.contributor.authorBramwell, Vivien H Cen
dc.contributor.authorThatcher, Nicken
dc.date.accessioned2010-07-21T09:47:50Z-
dc.date.available2010-07-21T09:47:50Z-
dc.date.issued1987-02-15-
dc.identifier.citationPretreatment prognostic factors and scoring system in 407 small-cell lung cancer patients. 1987, 39 (2):146-9 Int. J. Canceren
dc.identifier.issn0020-7136-
dc.identifier.pmid3026969-
dc.identifier.doi10.1002/ijc.2910390204-
dc.identifier.urihttp://hdl.handle.net/10541/108003-
dc.description.abstractIn 407 patients with small-cell lung cancer (SCLC), 61 pretreatment variables were evaluated in a Cox multiple regression analysis to assess their prognostic value. All patients received short-term intensive regimens (cyclophosphamide, etoposide and methotrexate or ifosfamide and etoposide, both followed by thoracic irradiation if complete response was noted). Lactate dehydrogenase (p = 0.001), tumour stage (p = 0.0001), serum sodium (p = 0.0009), pretreatment Karnofsky performance score (p = 0.0121), alkaline phosphatase (p = 0.0186) and serum bicarbonate (p = 0.0321) were the important prognostic factors. Once these variables were taken into account no other variable provided additional prognostic information. A simple scoring system ("Manchester Score") using these variables was established and shows little loss of information compared to the Cox analysis. The score distinguishes 3 prognostic groups, the best of which contains all long-term survivors, whereas the bad prognostic group contains no patient surviving longer than one year. The scoring system may help to design new treatment strategies and may also facilitate the comparison of different studies.en
dc.language.isoenen
dc.subjectLung Canceren
dc.subjectCancer Stagingen
dc.subject.meshCarcinoma, Small Cell-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLung Neoplasms-
dc.subject.meshMale-
dc.subject.meshNeoplasm Staging-
dc.subject.meshPrognosis-
dc.subject.meshRegression Analysis-
dc.titlePretreatment prognostic factors and scoring system in 407 small-cell lung cancer patients.en
dc.typeArticleen
dc.contributor.departmentInstitut fuer Medizinische Onkologie, Universitaet Bern, Inselspital, CH-3010 Bern, Switzerlanden
dc.identifier.journalInternational Journal of Canceren
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