The pharmacokinetics of ifosfamide given as short and long intravenous infusions in cancer patients.

2.50
Hdl Handle:
http://hdl.handle.net/10541/107855
Title:
The pharmacokinetics of ifosfamide given as short and long intravenous infusions in cancer patients.
Authors:
Lewis, L D; Fitzgerald, D L; Mohan, P; Thatcher, Nick; Harper, P G; Rogers, H J
Abstract:
1. We investigated the pharmacokinetics of ifosfamide 5 g m-2 given by two regimens. Six patients (one female), median age 55 (range 40-71) years, all with lung cancer received 5 g m-2 ifosfamide (median ifosfamide dose 8.95 g) as an intravenous infusion over 0.5 h with mesna. Four other cancer patients (all male) of median age 52.5 (range 23-72) years were studied on seven treatment occasions with 5 g m-2 ifosfamide (median ifosfamide dose 8.88 g) as a 24 h intravenous infusion with mesna. Plasma was assayed for ifosfamide by gas liquid chromatography and for alkylating activity by the nitrobenzylpyridine method. 2. After ifosfamide 5 g m-2 infused over 0.5 h, the decay of the plasma ifosfamide concentration was monoexponential with a median (range) t1/2,z of 5.4 h (3.6-10.4 h). The median clearance was 60 ml min-1 (47-104) and the median volume of distribution was 388 (329-783) ml kg-1. Plasma nitrobenzylpyridine alkylating activity showed a biexponential decay in four patients and a monoexponential decay in two, with a median AUC of 102 (24-177) nmol nor nitrogen mustard eq h ml-1. 3. When ifosfamide 5 g m-2 was given as a 24 h infusion, the decay of the plasma ifosfamide concentration was monoexponential, the median (range) t1/2,z was 4.5 (3.4-6.1), the median volume of distribution was 563 (292-818) ml kg-1 and the median clearance was 79 (59-116) ml min-1. Plasma nitrobenzylpyridine alkylating activity decayed monoexponentially and the median AUC was 49 (45-131) nmol nor nitrogen mustard eq ml-1 h.(ABSTRACT TRUNCATED AT 250 WORDS)
Affiliation:
Division of Clinical Pharmacology, United Medical School, Guy's Hospital, London.
Citation:
The pharmacokinetics of ifosfamide given as short and long intravenous infusions in cancer patients. 1991, 31 (1):77-82 Br J Clin Pharmacol
Journal:
British Journal of Clinical Pharmacology
Issue Date:
Jan-1991
URI:
http://hdl.handle.net/10541/107855
PubMed ID:
2015174
Type:
Article
Language:
en
ISSN:
0306-5251
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorLewis, L Den
dc.contributor.authorFitzgerald, D Len
dc.contributor.authorMohan, Pen
dc.contributor.authorThatcher, Nicken
dc.contributor.authorHarper, P Gen
dc.contributor.authorRogers, H Jen
dc.date.accessioned2010-07-17T10:25:56Z-
dc.date.available2010-07-17T10:25:56Z-
dc.date.issued1991-01-
dc.identifier.citationThe pharmacokinetics of ifosfamide given as short and long intravenous infusions in cancer patients. 1991, 31 (1):77-82 Br J Clin Pharmacolen
dc.identifier.issn0306-5251-
dc.identifier.pmid2015174-
dc.identifier.urihttp://hdl.handle.net/10541/107855-
dc.description.abstract1. We investigated the pharmacokinetics of ifosfamide 5 g m-2 given by two regimens. Six patients (one female), median age 55 (range 40-71) years, all with lung cancer received 5 g m-2 ifosfamide (median ifosfamide dose 8.95 g) as an intravenous infusion over 0.5 h with mesna. Four other cancer patients (all male) of median age 52.5 (range 23-72) years were studied on seven treatment occasions with 5 g m-2 ifosfamide (median ifosfamide dose 8.88 g) as a 24 h intravenous infusion with mesna. Plasma was assayed for ifosfamide by gas liquid chromatography and for alkylating activity by the nitrobenzylpyridine method. 2. After ifosfamide 5 g m-2 infused over 0.5 h, the decay of the plasma ifosfamide concentration was monoexponential with a median (range) t1/2,z of 5.4 h (3.6-10.4 h). The median clearance was 60 ml min-1 (47-104) and the median volume of distribution was 388 (329-783) ml kg-1. Plasma nitrobenzylpyridine alkylating activity showed a biexponential decay in four patients and a monoexponential decay in two, with a median AUC of 102 (24-177) nmol nor nitrogen mustard eq h ml-1. 3. When ifosfamide 5 g m-2 was given as a 24 h infusion, the decay of the plasma ifosfamide concentration was monoexponential, the median (range) t1/2,z was 4.5 (3.4-6.1), the median volume of distribution was 563 (292-818) ml kg-1 and the median clearance was 79 (59-116) ml min-1. Plasma nitrobenzylpyridine alkylating activity decayed monoexponentially and the median AUC was 49 (45-131) nmol nor nitrogen mustard eq ml-1 h.(ABSTRACT TRUNCATED AT 250 WORDS)en
dc.language.isoenen
dc.subjectLung Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAlkylation-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIfosfamide-
dc.subject.meshInfusions, Intravenous-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasms-
dc.subject.meshPyridines-
dc.titleThe pharmacokinetics of ifosfamide given as short and long intravenous infusions in cancer patients.en
dc.typeArticleen
dc.contributor.departmentDivision of Clinical Pharmacology, United Medical School, Guy's Hospital, London.en
dc.identifier.journalBritish Journal of Clinical Pharmacologyen

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