2.50
Hdl Handle:
http://hdl.handle.net/10541/107696
Title:
Clinical applications of interleukin-2.
Authors:
Von Rohr, A; Thatcher, Nick
Abstract:
Interleukin-2 (IL-2) is a cytokine with potent immunomodulating properties which has shown considerable antitumour activity in preclinical models. In clinical trials, the effects of IL-2 given by various routes and schedules have been investigated. IL-2 has been administered either as single drug or in combination with other cytokines and immunomodulating agents, chemo therapeutic agents, or reinfusions of ex vivo activated autologous cytotoxic effector cells. The results of published clinical studies with IL-2 based immunotherapy are reviewed in this paper.
Affiliation:
CRC Department of Medical Oncology, Christie Hospital, Manchester, U.K.
Citation:
Clinical applications of interleukin-2. 1992, 4 (3):229-46 Prog Growth Factor Res
Journal:
Progress in Growth Factor Research
Issue Date:
1992
URI:
http://hdl.handle.net/10541/107696
PubMed ID:
1307490
Type:
Article
Language:
en
ISSN:
0955-2235
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorVon Rohr, Aen
dc.contributor.authorThatcher, Nicken
dc.date.accessioned2010-07-15T09:07:16Z-
dc.date.available2010-07-15T09:07:16Z-
dc.date.issued1992-
dc.identifier.citationClinical applications of interleukin-2. 1992, 4 (3):229-46 Prog Growth Factor Resen
dc.identifier.issn0955-2235-
dc.identifier.pmid1307490-
dc.identifier.urihttp://hdl.handle.net/10541/107696-
dc.description.abstractInterleukin-2 (IL-2) is a cytokine with potent immunomodulating properties which has shown considerable antitumour activity in preclinical models. In clinical trials, the effects of IL-2 given by various routes and schedules have been investigated. IL-2 has been administered either as single drug or in combination with other cytokines and immunomodulating agents, chemo therapeutic agents, or reinfusions of ex vivo activated autologous cytotoxic effector cells. The results of published clinical studies with IL-2 based immunotherapy are reviewed in this paper.en
dc.language.isoenen
dc.subjectTumour-Infiltrating Lymphocytesen
dc.subject.meshClinical Trials as Topic-
dc.subject.meshCombined Modality Therapy-
dc.subject.meshCytokines-
dc.subject.meshDose-Response Relationship, Drug-
dc.subject.meshHumans-
dc.subject.meshImmunotherapy, Adoptive-
dc.subject.meshInterleukin-2-
dc.subject.meshKiller Cells, Lymphokine-Activated-
dc.subject.meshLymphocytes, Tumor-Infiltrating-
dc.titleClinical applications of interleukin-2.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Medical Oncology, Christie Hospital, Manchester, U.K.en
dc.identifier.journalProgress in Growth Factor Researchen

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