Recombinant interleukin-2 in metastatic renal cell carcinoma--a European multicentre phase II study.
Authors
von der Maase, HGeertsen, P
Thatcher, Nick
Jasmin, C
Mercatello, A
Fosså, S D
Symann, M
Stoter, G
Nagel, G
Israel, L
Affiliation
Department of Oncology, Herlev University Hospital, Copenhagen, Denmark.Issue Date
1991
Metadata
Show full item recordAbstract
This multinational, multicentre study represents the introduction of recombinant interleukin-2 (rIL-2) in Europe. From December 1987 to June 1989, 57 eligible patients with metastatic renal cell cancer were treated with rIL-2 administered as continuous intravenous infusion. 8 out of 51 evaluable patients responded (16%), 2 complete remission (CR) and 6 partial remission (PR). 10 patients had no change (20%). The response duration for CR was 209 and 394+ days. The median response duration for PR was 371 (range 140-506+) days. Dose-limiting grade 3-4 toxicities were hypotension in 52% of the patients, arrhythmia (4%), dyspnoea (8%), creatinine rise (4%), peripheral neurotoxicity (10%) and central neurotoxicity (10%). Toxicities most often recovered solely on interrupted therapy. 2 patients died due to catheter-related septicaemia and one patient died of rIL-2 induced renal failure. The study confirmed the antitumour efficacy of rIL-2 in renal cell cancer. Toxicities were numerous, but manageable by close observation in a normal oncology ward without routine use of an intensive care unit.Citation
Recombinant interleukin-2 in metastatic renal cell carcinoma--a European multicentre phase II study. 1991, 27 (12):1583-9 Eur J CancerJournal
European Journal of CancerPubMed ID
1782066Type
ArticleLanguage
enISSN
0959-8049Collections
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