DNA analysis by flow cytometry in malignant pleural mesothelioma: relationship to histology and survival.

2.50
Hdl Handle:
http://hdl.handle.net/10541/107656
Title:
DNA analysis by flow cytometry in malignant pleural mesothelioma: relationship to histology and survival.
Authors:
Dazzi, H; Thatcher, Nick; Hasleton, Philip S; Chatterjee, A K; Lawson, R A
Abstract:
In a retrospective study of 70 patients with malignant pleural mesothelioma, 168 formalin-fixed, paraffin-embedded tumour specimens were examined for DNA content by flow cytometry. In 20 patients where two or more blocks of the same tumour were available, there was considerable agreement between ploidy status and S-phase percentage in the different specimens. There were no significant differences for survival for patients who had been exposed to asbestos and those in whom no exposure could be elicited, nor for aneuploid and diploid tumours. The S-phase content was examined for different areas of the same tumour and the percentages were largely in agreement. However, those patients who had tumours with an S-phase percentage greater than the median (6 per cent) had a significantly shorter survival than those with tumours of lower S-phase percentage. Differences in DNA content and other cell cycle parameters were not associated with the histological subtypes.
Affiliation:
CRC Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Manchester, U.K.
Citation:
DNA analysis by flow cytometry in malignant pleural mesothelioma: relationship to histology and survival. 1990, 162 (1):51-5 J Pathol
Journal:
The Journal of Pathology
Issue Date:
Sep-1990
URI:
http://hdl.handle.net/10541/107656
DOI:
10.1002/path.1711620110
PubMed ID:
2231193
Type:
Article
Language:
en
ISSN:
0022-3417
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorDazzi, Hen
dc.contributor.authorThatcher, Nicken
dc.contributor.authorHasleton, Philip Sen
dc.contributor.authorChatterjee, A Ken
dc.contributor.authorLawson, R Aen
dc.date.accessioned2010-07-14T16:50:46Z-
dc.date.available2010-07-14T16:50:46Z-
dc.date.issued1990-09-
dc.identifier.citationDNA analysis by flow cytometry in malignant pleural mesothelioma: relationship to histology and survival. 1990, 162 (1):51-5 J Patholen
dc.identifier.issn0022-3417-
dc.identifier.pmid2231193-
dc.identifier.doi10.1002/path.1711620110-
dc.identifier.urihttp://hdl.handle.net/10541/107656-
dc.description.abstractIn a retrospective study of 70 patients with malignant pleural mesothelioma, 168 formalin-fixed, paraffin-embedded tumour specimens were examined for DNA content by flow cytometry. In 20 patients where two or more blocks of the same tumour were available, there was considerable agreement between ploidy status and S-phase percentage in the different specimens. There were no significant differences for survival for patients who had been exposed to asbestos and those in whom no exposure could be elicited, nor for aneuploid and diploid tumours. The S-phase content was examined for different areas of the same tumour and the percentages were largely in agreement. However, those patients who had tumours with an S-phase percentage greater than the median (6 per cent) had a significantly shorter survival than those with tumours of lower S-phase percentage. Differences in DNA content and other cell cycle parameters were not associated with the histological subtypes.en
dc.language.isoenen
dc.subjectCancer DNAen
dc.subjectPleural Canceren
dc.subject.meshAged-
dc.subject.meshAsbestos-
dc.subject.meshDNA, Neoplasm-
dc.subject.meshFemale-
dc.subject.meshFlow Cytometry-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMesothelioma-
dc.subject.meshMiddle Aged-
dc.subject.meshPleural Neoplasms-
dc.subject.meshPloidies-
dc.subject.meshRetrospective Studies-
dc.titleDNA analysis by flow cytometry in malignant pleural mesothelioma: relationship to histology and survival.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Manchester, U.K.en
dc.identifier.journalThe Journal of Pathologyen
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