DNA analysis by flow cytometry in nonsmall cell lung cancer: relationship to epidermal growth factor receptor, histology, tumour stage and survival.

2.50
Hdl Handle:
http://hdl.handle.net/10541/107655
Title:
DNA analysis by flow cytometry in nonsmall cell lung cancer: relationship to epidermal growth factor receptor, histology, tumour stage and survival.
Authors:
Dazzi, H; Thatcher, Nick; Hasleton, Philip S; Swindell, Ric
Abstract:
In a retrospective study, surgical specimens of 136 patients with nonsmall cell lung cancer, were investigated for DNA content by flow cytometry. Seventy per cent of all tumours were aneuploid. Aneuploidy was a statistically significant factor for shorter survival and was independent of tumour size, histology, grade of differentiation, regional lymph node involvement, age and sex (P less than 0.02). A high proliferation index (greater than 7.5%) was also a prognostically unfavourable factor and was observed significantly more often in tumours where the majority of cells expressed epidermal growth factor receptor.
Affiliation:
CRC Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Manchester, U.K.
Citation:
DNA analysis by flow cytometry in nonsmall cell lung cancer: relationship to epidermal growth factor receptor, histology, tumour stage and survival. 1990, 84 (3):217-23 Respir Med
Journal:
Respiratory Medicine
Issue Date:
May-1990
URI:
http://hdl.handle.net/10541/107655
PubMed ID:
2171051
Type:
Article
Language:
en
ISSN:
0954-6111
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorDazzi, Hen
dc.contributor.authorThatcher, Nicken
dc.contributor.authorHasleton, Philip Sen
dc.contributor.authorSwindell, Ricen
dc.date.accessioned2010-07-14T16:26:26Z-
dc.date.available2010-07-14T16:26:26Z-
dc.date.issued1990-05-
dc.identifier.citationDNA analysis by flow cytometry in nonsmall cell lung cancer: relationship to epidermal growth factor receptor, histology, tumour stage and survival. 1990, 84 (3):217-23 Respir Meden
dc.identifier.issn0954-6111-
dc.identifier.pmid2171051-
dc.identifier.urihttp://hdl.handle.net/10541/107655-
dc.description.abstractIn a retrospective study, surgical specimens of 136 patients with nonsmall cell lung cancer, were investigated for DNA content by flow cytometry. Seventy per cent of all tumours were aneuploid. Aneuploidy was a statistically significant factor for shorter survival and was independent of tumour size, histology, grade of differentiation, regional lymph node involvement, age and sex (P less than 0.02). A high proliferation index (greater than 7.5%) was also a prognostically unfavourable factor and was observed significantly more often in tumours where the majority of cells expressed epidermal growth factor receptor.en
dc.language.isoenen
dc.subjectCancer DNAen
dc.subjectLung Canceren
dc.subject.meshCarcinoma, Non-Small-Cell Lung-
dc.subject.meshDNA, Neoplasm-
dc.subject.meshFlow Cytometry-
dc.subject.meshHumans-
dc.subject.meshLung Neoplasms-
dc.subject.meshPloidies-
dc.subject.meshPrognosis-
dc.subject.meshReceptor, Epidermal Growth Factor-
dc.subject.meshRetrospective Studies-
dc.titleDNA analysis by flow cytometry in nonsmall cell lung cancer: relationship to epidermal growth factor receptor, histology, tumour stage and survival.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Manchester, U.K.en
dc.identifier.journalRespiratory Medicineen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.