The effect of route of administration and fractionation of dose on the metabolism of ifosfamide.

2.50
Hdl Handle:
http://hdl.handle.net/10541/107653
Title:
The effect of route of administration and fractionation of dose on the metabolism of ifosfamide.
Authors:
Lind, Michael J; Roberts, H L; Thatcher, Nick; Idle, J R
Abstract:
The measurement of urinary ifosfamide, isophosphoramide mustard, dechloroethyl ifosfamide and carboxyifosfamide using high-performance thin-layer chromatography with photographic densitometry (TLC-PD) is described. This technique was also used to demonstrate the large inter-individual variation in the ifosfamide metabolic profile of patients receiving the drug as single-agent therapy for non-small-cell lung cancer. In addition, oral administration was shown to result in higher levels of these metabolites in the urine. Fractionation of the ifosfamide dose over several days resulted in increasing levels of metabolites in the urine, consistent with auto-induction of ifosfamide metabolism.
Affiliation:
CRC Department of Medical Oncology, Christie Hospital and Holt Radium Institute Manchester, UK.
Citation:
The effect of route of administration and fractionation of dose on the metabolism of ifosfamide. 1990, 26 (2):105-11 Cancer Chemother Pharmacol
Journal:
Cancer Chemotherapy and Pharmacology
Issue Date:
1990
URI:
http://hdl.handle.net/10541/107653
PubMed ID:
2347037
Type:
Article
Language:
en
ISSN:
0344-5704
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorLind, Michael Jen
dc.contributor.authorRoberts, H Len
dc.contributor.authorThatcher, Nicken
dc.contributor.authorIdle, J Ren
dc.date.accessioned2010-07-14T16:08:18Z-
dc.date.available2010-07-14T16:08:18Z-
dc.date.issued1990-
dc.identifier.citationThe effect of route of administration and fractionation of dose on the metabolism of ifosfamide. 1990, 26 (2):105-11 Cancer Chemother Pharmacolen
dc.identifier.issn0344-5704-
dc.identifier.pmid2347037-
dc.identifier.urihttp://hdl.handle.net/10541/107653-
dc.description.abstractThe measurement of urinary ifosfamide, isophosphoramide mustard, dechloroethyl ifosfamide and carboxyifosfamide using high-performance thin-layer chromatography with photographic densitometry (TLC-PD) is described. This technique was also used to demonstrate the large inter-individual variation in the ifosfamide metabolic profile of patients receiving the drug as single-agent therapy for non-small-cell lung cancer. In addition, oral administration was shown to result in higher levels of these metabolites in the urine. Fractionation of the ifosfamide dose over several days resulted in increasing levels of metabolites in the urine, consistent with auto-induction of ifosfamide metabolism.en
dc.language.isoenen
dc.subject.meshAdministration, Oral-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshChromatography, Thin Layer-
dc.subject.meshCyclophosphamide-
dc.subject.meshDensitometry-
dc.subject.meshDrug Administration Schedule-
dc.subject.meshHumans-
dc.subject.meshIfosfamide-
dc.subject.meshInfusions, Intravenous-
dc.subject.meshMiddle Aged-
dc.subject.meshPhosphoramide Mustards-
dc.titleThe effect of route of administration and fractionation of dose on the metabolism of ifosfamide.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Medical Oncology, Christie Hospital and Holt Radium Institute Manchester, UK.en
dc.identifier.journalCancer Chemotherapy and Pharmacologyen

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